Inflammatory response to dietary linoleic acid depends on FADS1 genotype
Two things come out that are worth noting. First is that, from Fig 4, that increased dietary LA mostly decreases the arachidonic acid in plasma phospholipids and cholesterol esters. I made a throw away comment in a previous post that I would expect supplementing any C18 PUFA would inhibit the formation of any C20 and C22 fatty acids. I got lucky on that one, AA levels mostly dropped with LA supplementation, one didn't change.
Much more interesting is the effect of the intervention, irrespective of genotype, on food intake. Like this:
"Based on food records, energy intake was significantly increased during the intervention period, which could be considered a third limitation. However, there were no changes in body weight or BMI, and an increase in energy intake was similar in both genotype groups. It is likely that the increased energy intake was at least partly related to the fact that oil consumption was carefully recorded during the intervention period."
I think we can describe this "likely" effect as ad hoc hypothesis number 3264.
A more reasonable ad hoc hypothesis is that increasing your linoleic acid intake from 4% of calories to 11% of calories makes you hungry. If this change were to have been caused by a projected loss of half a kilo of ingested lipid in to adipocytes over a year, that would be less than 50g per month. Easily masked by a number of biological variations.
Peter
