Hi everyone,
Hyperlipid is now getting back to a reasonable semblance of normality. I'll try to answer the comments as soon as I can. What happened? Well, about six weeks ago I was invited to join THINCS. Within two weeks of my email address going up on the THINCS website I was invited by the Skeptics Society of St Paul's School in London to present a 40 minute overview of why I was unconvinced by the lipid hypothesis of CHD. After some initial teething problems due to lack of software ownership (resulting in a crash course of teach yourself Powerpoint on my wife's PC), I got a presentation together. It was two and a half hours long. Major butchery got it down to an hour and a half. Has anyone ever tried to demolish the lipid hypothesis in just over 30 minutes?
The presentation was last Tuesday and it was a really enjoyable day for all of us. Staff and sixthformers were very interested and the discussion carried on over lunch. I had pitched the talk as neutral as possible, just draw the graphs, discuss the studies and let the science speak for itself. Never mind statin bashing or the weird data from the 4S study.
Interestingly, most of the audience were perfectly willing to draw their own conclusions about data manipulation if you show them Yerushalmy and Hilleboe's paper analysing Keys' Six Countries Study (many thanks Alex). I never did mention the 4S study data.
A number of people commented, positively, on this fairly dead pan approach. You don't need to be aggressive or sarcastic to make your point when the facts speak for themselves so clearly.
It all took a great deal of preparation. In addition to this my wife is in the last two weeks of the lab work of her PhD (she has ligands, that's good! Woohoo, happy dance) and will start writing up over Christmas... Anyone who has played the PhD game will know exactly what this has meant for the last few months and what it will mean for the next few months. PhDs are not intended to be recreational!
So posting when I can and I'll answer the off blog outstanding emails soon. When I get to comments about a discussion forum, I agree, it would be a great idea but I think it would be impossible to do at the present time from my commitment perspective. I'm about 350 emails behind (just reading) on the THINCS discussion board at the moment.
Peter
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You need to get calories from somewhere, should it be from carbohydrate or fat?
About Me
- Peter
- I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
Organisation (or lack of it)!
The "labels" function on this blog has been used to function as an index and I've tended to group similar subjects together by using labels starting with identical text. If they're numbered within a similar label, start with (1). The archive is predominantly to show the posts I've put up in the last month, if people want to keep track of recent goings on. I might change it to the previous week if I ever get to time to put up enough posts in a week to justify it. That seems to be the best I can do within the limits of this blogging software!
Blog Archive
Labels
- !Kung Bushmen and mongongo nuts again (1)
- !Kung Bushmen and mongongo nuts yet again (1)
- A aargh BROKEN LINKS (1)
- A bit more on ketones and diabetic nephropathy (1)
- A brief aside in to statins and FH and all cause mortality (1)
- A brief discussion of ketosis (1)
- A defect of fat metabolism and a few thanks (1)
- A glimmer of light (1)
- A heads up (1)
- A little more on PCSK9 inhibitors (1)
- A load of crap in Gartnavel (1)
- A Peek at Paleo (1)
- A post not about Walter Kempner (1)
- A tale of two abstracts (1)
- A wander off in to dietary protein calories (1)
- ACCORD and musings on insulin (1)
- Acetoacetate and arterial oxygen tension (1)
- Acetone to oxaloacetate (1)
- Acipimox (2) and weight gain (1)
- Acipimox and insulin (1)
- Acipimox and insulin action (1)
- Adipose triglyceride lipase knockout mice (1)
- Adipotide and the Bad Fat (1)
- Adrian Ballinger on Everest (1)
- AGE RAGE and ALE (1): The AGE of LDL (1)
- AGE RAGE and ALE (2): The ALE of LDL (1)
- AGE RAGE and ALE (3): oxLDL (1)
- AGE RAGE and ALE (4): segregation (1)
- AGE RAGE and ALE (5): fasting (1)
- AGE RAGE and ALE (6): low fat (1)
- AGE RAGE and ALE (7): VLDL degradation (1)
- AGE RAGE and ALE (8): VLDL degradation and Krauss (1)
- AGE RAGE and ALE (9): VLDL degradation and Fish Oil (1)
- AGE RAGE and ALE posts (10): small dense Krauss (1)
- AGE RAGE and ALE posts (11): linoleic acid (1)
- AHA approved egg! (1)
- Alcohol and fructose are the same to your liver (1)
- Alcohol and weight loss (1)
- Alzheimer's (1)
- Alzheimers and ketones (1)
- Alzheimers and omega 6s (1)
- Alzheimers and Tau proteins (1) (1)
- Alzheimers and Tau proteins (2) (1)
- Amgen share price and PCSK9 inhibition with Repatha (1)
- Amgen share price and PCSK9 inhibition with Repatha (2) (1)
- an aside (1)
- An aside on psychiatric links from Sid Dishes (1)
- An embarrassment of cress (1)
- An Error (1)
- An exchange of half bricks (1)
- Anacetrapib and phytotoxins (1)
- Anger vs diet in Japan (1)
- Animal fat and cholesterol (1)
- ARDS and linoleic acid (1)
- ARDS and Tucker Goodrich (1)
- ARDS isoprostanes and isofurans (1)
- Are COVID-19 vaccines useful? (1)
- Are COVID-19 vaccines useful? (2) (1)
- Are COVID-19 vaccines useful? (3) (1)
- Are humans just multicellular yeasts? (1)
- Are ketone esters dangerous? (1)
- Are you lino-philic? (2) (1)
- Are you on clenbuterol? (3) (1)
- Are you trans-phobic? (1) (1)
- Arteriosclerosis (1) in 1957 (1)
- Arteriosclerosis (2) and sulphation factor (1)
- Arteriosclerosis (3) and von Willebrand Disease (1)
- Arteriosclerosis (4) GAG and sudden death (1)
- Arteriosclerosis (5) GAG and sudden death part two; the pictures (1)
- Arteriosclerosis (6) and Subbotin (1)
- Arteriosclerosis and saturated fat (1)
- Arteriosclerosis and the breeder rat (1)
- Arteriosclerosis images (2): Models (1)
- Athletic acid reflux (1)
- Atrial tachycardia and fibrillation (1)
- Axen and Axen (1) (1)
- Axen and Axen (2) (1)
- Axen and Axen (3) Hawks (1)
- Axen and Axen (4) Ketogenic insulin resistance. It's all over now... (1)
- Axen and Axen (5) The tradition continues (1)
- Back on line (2)
- Back to a semblance of normality: A couple of conversations (1)
- BAM15 and semaglutide are not insulin sensitising (1)
- Barja (1)
- Best ever statin study comment? (1)
- Best ever statin study? (1)
- Beta oxidation intermediates control ETC function (1)
- Blood "energy" content (1)
- Bob Michell on meta-analysis (1)
- Boiled mashed potatoes for miracle weight loss? (1)
- Boxes (1)
- Brain on a statin (1)
- Brain on chocolate (1)
- Brand insights (1)
- Brand on 4-HNE facilitated uncoupling (1)
- Breast cancer and starch (1)
- Breast cancer BRCA1 and metabolic syndrome (1)
- butter and leptin receptors: Speculation! (1)
- Butter gives you fatty liver! Again. (1)
- Butter insulin and Dr Davis (1)
- Butter vs peanut butter (1)
- Can linoleic acid keep you slim? (1)
- Cancer and ketones (1)
- Cardiac ischaemia and low carbohydrate diets (1)
- Casein and gluten and gastric pH (1)
- Casein vs gluten (1)
- Cat rawfeeding; scroll down the comments (1)
- Cell surface oxygen consumption (1) (1)
- Cell surface oxygen consumption (2) (1)
- Cell surface oxygen consumption (3) (1)
- Cell surface oxygen consumption (4) Influenza (1)
- Chicken fillets are not meat. If you're a cat. (1)
- Cholesterol (the HDL sort) kills? (1)
- Cholesterol and Carruthers (1)
- Cholesterol and cholestyramine (1)
- Cholesterol and heart attack survival (1)
- Cholesterol and innate immunity (1)
- Cholesterol and memory (1)
- Cholesterol and Son of J-LIT (1)
- Cholesterol and the J-LIT study (1)
- Cholesterol and the J-LIT update (1)
- Cholesterol fed rabbit (1)
- Cholesterol heart attacks and JUPITER (1)
- Cholesterol hypothesis in 2010 (1)
- Cholesterol hypothesis in 2010 part 2 (1)
- Cholesterol JUPITER link (1)
- Cholesterol Milano style (1)
- Cholesterol pacitimbe and ACAT (1)
- Cholesterol presentation: Between countries (1)
- Cholesterol ratios through the looking glass (1)
- Cholesterol ratios: Torcetrapib again (1)
- Cholesterol reflectivity at 400nm (1)
- Cholesterol within nations studies (1)
- Cholesterol; it's not a competition (1)
- Cholesterol; MESA and EBCT (1)
- Cholesterol; statins kill? (1)
- Cholesterol: ASTEROID destroys lipid hypothesis (1)
- Cholesterol: Do chylomicrons clog your arteries? (1)
- Cholesterol: Do chylomicrons clog your arteries? (2) (1)
- Cholesterol: LCAT and rabbits (1)
- Cholesterol: LDL in Oslo (1)
- Cholesterol: More epidemiology (1)
- Cholesterol: Near miss in Edinburgh (1)
- Cholesterol: Peto seeing some light? (1)
- Cholesterol: statins and oxLDL (1)
- Choose your insulin sensitivity well (1)
- Cirrhosis and corn oil (1)
- Cirrhosis and fish oil (1)
- Cirrhosis and fructose (1)
- Clofibrate and PUFA (1)
- Coconut oil and obesity (1)
- Coconuts and Cornstarch in the Arctic? (1)
- Coffee (1)
- Colorectal cancer and cholesterol (1)
- Colorectal cancer; fiber and the PPT (1)
- Complex I: Hoffer and B3 (1)
- Complex IV and control of delta psi (1)
- Conditioning Research on bad carbs (1)
- Confirmation Bias in my head (1)
- Confirmation bias is not just in my head (1)
- Confirmation bias is so nice (1)
- Coronary Artery Calcium Score and Scleroderma (1)
- Coronavirus is possibly everywhere (1)
- Costa del Glasgow (1)
- Covid playground (1)
- COVID-19 (1)
- CPT1aL479 resurfaces nicely (1)
- Crabtree and cardiovascular surgery (1)
- Credo (1)
- Cynthia Kenyon link (1)
- Dave Asprey and Dr Veech (1)
- David Blaine and refeeding syndrome (1)
- Dead people DO bleed... (1)
- Death by dogma (1)
- Delta psi and insulin and ROS (1)
- Delta psi and ROS (1)
- Denmark purchased using Flora profits? (1)
- Deuterium protected linoleic acid (1)
- DHA in rats (1)
- Diabetes and cardiac apotosis (1)
- Diabetes and hunger (1)
- Diabetes in Sweden (1)
- Diabetes in Sweden update (1)
- Diabetes; endothelial damage (1)
- Diabetic and hungry? (1)
- Diabetic nephropathy and the lost Swede (1)
- Diagnosing and Treating Vitamin B12 Deficiency Video (1)
- Do you believe in MRI scanners? (1)
- Dodgy D'Anci (1)
- Double Bond Index and longevity in humans (1)
- Dr Davis links (1)
- Dr Doug Wallace on mitochondria (1)
- Dr Ravnskov on statins for primary prevention of CVD (1)
- Dr Uffe Ravnskov MD PhD interview (1)
- Dr Wolfgang Lutz Obituary (1)
- Dunnigan Familial Partial Lipodystrophy (1)
- Earning a crust (1)
- Easiyo (1)
- Eat as much starch as you wish (1)
- Eating lots of meat and nothing much else (1)
- EBCT scan (1)
- EFA deficiencies? (1)
- Eggs are here (1)
- Eggs in Ontario (1)
- Electrochemistry (1)
- Electrochemistry (2) Superoxide (1)
- Electron Transport Chain image (1)
- Endocannabinoids in brain and adipocytes (1)
- Endotoxin Absorption on a High Fat Diet (1)
- Endurance and oxygen flux during fatty acid oxidation (1)
- Energy expenditure in obese vs slim non dieters (1)
- EPIC HbA1c and heart attacks (1)
- Essential fatty acids are essential (1)
- Excession (1)
- Faking it with selenium (1)
- Familial Hypercholesterolaemia (1)
- Familial Hypercholesterolaemia and glucose (1)
- Familial Hypercholesterolaemia and porcelain (1)
- Familial Hypercholesterolaemia Brown and Goldstein (1)
- Familial Hypercholesterolaemia heterozygous survival (1)
- Fancy some serology? (1)
- Fancy some serology? (2) (1)
- Fancy some serology? (3) In Japan (1)
- Fasting insulin and weight loss (1)
- Fasting insulin and weight loss and calories-in vs calories-out (1)
- Fasting insulin and weight loss on a water fast (1)
- Fat storage and retrieval (1)
- Fathead Supersize Me and Sweden (1)
- Fathead Supersize Me and Sweden (2) (1)
- Fats and absorbing endotoxin (1)
- Feeling experimental? (1)
- FFA vs 4-HNE for activating uncoupling (1)
- Fiaf (1) Who's fat is it anyway? (1)
- Fiaf (2) starving amidst plenty (1)
- Fiaf (3) where next? (1)
- Fiaf (4) memes and fat (1)
- Fiaf (5) Meme Watching (1)
- Fiber inulin and cancer (1)
- Fiber sucrose and ulcers (1)
- FIP vaccines etc (1)
- FIRKO mice (1)
- FIRKO-isation without all the hassle? (1)
- FIRKO-ise (1)
- First meat (1)
- Flow Mediated Dilation: What does it mean? (1)
- Foie Gras (1) Peroxisomes (1)
- Foie Gras (10) Liver (1)
- Foie Gras (11) Hepatocyte mitochondria (1)
- Foie Gras (2) Lard fed rats (1)
- Foie Gras (3) carbohydrate (1)
- Foie Gras (4) RER (1)
- Foie Gras (5) An aside on how to stay slim (1)
- Foie Gras (6) inflammatory mRNAs (1)
- Foie Gras (7) What do you mean by inflammation? (1)
- Foie Gras (8) Vaughan's macrophages (1)
- Foie gras (9) Adipocyte ROS (1)
- Foie gras from safflower oil hiatus (1)
- Folate and homocysteine (1)
- Follow on to Tucker's post on PUFA in rats (1)
- Food fermented cream (1)
- Food; carnitas (1)
- Food; chicken salsa (1)
- Food; Mutton followed by cheesecake (1)
- Food; sausages (1)
- Food; steak and kidney casserole (1)
- Food: African Beef Stew (1)
- Food: Burgers (1)
- Food: Lardo; the real thing (1)
- Food: Liver and bacon (1)
- Food: Liver; can you over do it? (1)
- Food: Mutton or lamb in orange sauce (1)
- Food: Offal (1)
- Food: Optimal ice cream (1)
- Food: Pork in green salsa and random dessert (1)
- Food: Recipe group (1)
- Food: steak and kidney casserole (1)
- French paradox in Sweden (1)
- From Yeasts to Chloroquine (1)
- Fructose (01) There's a signal (1)
- Fructose (02) Obesogen (1)
- Fructose (03) NOX vs RET (1)
- Fructose (04) Normal Adults (1)
- Fructose (05) Four out of five diabetics (1)
- Fructose (06) Acipimox tangent (1)
- Fructose (07) Acipimox tangent II (1)
- Fructose (08) Acipimox and FFAs (1)
- Fructose (09) The Surwit hepatocyte (1)
- Fructose (10) A can of cola (1)
- Fructose and gout (1) (1)
- Fructose and gout (2) (1)
- Fructose and heart attacks (1)
- Fructose and lactic acid in Naked Mole Rats (1)
- Fructose and leptin (1)
- Fructose and lipolysis (1)
- Fructose and metabolic syndrome: Uric acid (1)
- Fructose and triglycerides (1)
- Fructose Glucose and Cholesterol (1)
- Fruit and vegetables (1) cause DNA damage (1)
- Fruit and vegetables (1) re post (1)
- Fruit and vegetables (10) WHI and cancer (1)
- Fruit and vegetables (11) link (1)
- Fruit and vegetables (12) WHEL and CVD (1)
- Fruit and vegetables (13) become eggs (1)
- Fruit and vegetables (14) Listeriosis is no fun (1)
- Fruit and vegetables (2) damage your DNA... latest study headline (1)
- Fruit and vegetables (3) last post (almost) (1)
- Fruit and vegetables (4) The asterisk (1)
- Fruit and vegetables (5) in Holland (1)
- Fruit and vegetables (6) WHEL study (1)
- Fruit and Vegetables (7) Mediterranean France (1)
- Fruit and vegetables (8) WHEL study and McDougall (1)
- Fruit and vegetables (9) potato fruits (1)
- Fruit Flies and NDI1 (1)
- FSA apple (1)
- FSA in Glasgow (1)
- Full blown linoleic acid deficiency: speculation (1)
- Getting fat (1) staying fat (1)
- Getting fat (2) staying fat; follow on (1)
- Getting fat (3) is good (1)
- Getting fat (4) is bad when you stop (1)
- Getting fat (5) Hunger (1)
- Getting fat is good (6) Official (1)
- GLP-1 agonists (1)
- Glucosamine and aged mice (1)
- Glucose as a cure for hypertriglyceridaemia? (1)
- Glucose from fatty acids: RQ of 0.454 (1)
- Glucose lactate and cancer (1)
- Gluten and cardiomyopathy (1)
- Gluten and gall bladders (1)
- Gluten and NK cells (forget the antibodies) (1)
- Gluten and rheumatoid arthritis (1)
- Gluten and schizophrenia SPECT scan (1)
- Gluten ataxia (1)
- Gluten coeliac and multiple sclerosis (1)
- Gluten Dr Briffa link (1)
- Gluten links from Bloggeier (1)
- Gluten poppy pictures (1)
- Gluten-Congratulations: You have coeliac disease (1)
- Gluten; thyroid and auto immunity (1)
- Gluten: Does coeliac disease require an infection? (1)
- Gluten: Not your average plant toxin? (1)
- Gluten: The NICE guidelines for UK diagnosis (1)
- Glycaemic load and breast cancer (1)
- Gourmand Rats? (1)
- Great Barrington Declaration (1)
- Great Barrington Declaration (2) (1)
- Green Tea Extract; superb antioxidant? (1)
- GSD IIIa ketones MAD and Veech again (1)
- GSD type I vs GSD type III: Cornstarch vs ketones (1)
- Guddling in the dark (1)
- Guddling in the dark for a respiratory quotient (2) (1)
- Guess the weight of the mouse competition (1)
- Gwyneth Paltrow has osteopaenia (1)
- Hall and CICO again (1)
- Hall and CICO part 2 (1)
- Hall and CICO part 3 (1)
- Have you thought about electron transporting flavoprotein dehydrogenase and its substrate electron transporting flavoprotein? (1)
- Hazel eats butter (1)
- HbA1c and Familial Hypercholesterolaemia (1)
- HbA1c: Crack vs smack for a lower reading? (1)
- HbA1c: Low glucose and acid (palmitic) (1)
- Heart failure and insulin resistance (1)
- Helicobacter and glucose (1)
- Helicobacter and hydrogen (1)
- Hepatic extraction of fructose (1)
- Hepatic insulin resistance (1)
- Hepatic insulin resistance in KD fed mice (1)
- Hepatic insulin resistance through caloric overload (1)
- Here we go in to Lockdown 2 (1)
- Heroin and IBS (1)
- High fat diet and fertility (1)
- High fat diets make you fat and stupid (1) (1)
- High fat diets make you fat and stupid (2) (1)
- High fat Dutch style (1)
- High fat fed mice on stearic acid (1)
- High fat meal is analgesic (1)
- HLA-B27 and Ebringer (1)
- HLA-B27 and Ebringer BSE text (1)
- HLA-B27 and Ebringer speech text (1)
- HLA-B27 some more (1)
- Holiday reading (1)
- How can insulin resistance cause weight gain? (1) ALDH2 (1)
- How can insulin resistance cause weight gain? (2) 0.1 μM (1)
- How can insulin resistance cause weight gain? (3) AD-9308 (1)
- How can insulin resistance cause weight gain? (4) amplification (1)
- How can insulin resistance cause weight gain? (5) MCTs (1)
- How incomplete was LUCA? (1)
- HOW MANY bananas a day? (1)
- How many eggs per day? (1)
- How much linoleic acid to get fat and insulin resistant? (1)
- How toxic is wheat? (1)
- How's it going (1)
- Hunting gathering and starving (1)
- Hyperglycaemia and free radicals (1)
- Hyperglycaemia is bad (1)
- Hyperlipid Protons ambassadors (1)
- I'm back (1)
- If there were time... (1)
- IgG IgA and sniffing a virus (1)
- IgG IgA and sniffing a virus which stinks (1)
- IHD and ghee (1)
- IHD single vessel disease (1)
- IHD Tracking plaque 1950s style (1)
- Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state (1)
- In the gym (1)
- Inhibiting lipolysis using acipimox (1)
- Insulin and confusion (1)
- Insulin and the Rewards of overfeeding (1)
- Insulin detemir (1) (1)
- Insulin detemir (2) (1)
- Insulin detemir (3) (1)
- Insulin glucagon and protein (1)
- Insulin in the brain: Hyperphagia? (1)
- Insulin in the brain: off topic giggle (1)
- Insulin increases coupling in mitochondria (1)
- Insulin makes you hungry (1) (1)
- Insulin makes you hungry (10) Processing (1)
- Insulin makes you hungry (2) even in the presence of hyperglycaemia (1)
- Insulin makes you hungry (3) a matter of semantics and free fatty acids (1)
- Insulin makes you hungry (4) unless you keep it out of your brain (1)
- Insulin makes you hungry (5) except when you resist (1)
- Insulin makes you hungry (6) except when you snort it (1)
- Insulin makes you hungry (7) superoxide is satiety (1)
- Insulin makes you hungry (8) Blokes (1)
- Insulin makes you hungry (9) Women (1)
- Insulin mimesis and NOX enzymes (1) A principle (1)
- Insulin mimesis and NOX enzymes (2) Lactate (1)
- Insulin mimesis and NOX enzymes (3) MCT (1)
- Insulin mimesis without NOX enzymes (4) MCT (1)
- Insulin mimesis without NOX enzymes (5) MCT plus linoleic acid (1)
- Insulin mimesis without NOX enzymes (6) MCT versus linoleic acid (1)
- Insulin sensitivity makes you fat (1)
- Insulin sensitivity makes you fat: growth hormone receptor deletion (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (02) (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (03) Visceral vs subcutaneous (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (04) M scores (1)
- Insulin; the Un-dead and coffin nails (1)
- Insulin: Are you hungry? (1)
- Insulin: Are you hungry? Part 2 (1)
- Insulin: The Flatline Days (1)
- Intellectual honesty vs obfuscation (1)
- Interesting times on Mars (1)
- Intimal wall volume reductions with weight loss (1)
- Is the astrocyte-neuron lactate shuttle finished? (1)
- Is vaccine efficacy a statistical illusion? (1)
- It's never too late to normalise your glucose (so long as you are still alive) (1)
- Jan Kwasniewski comment (1)
- Japan and a Seven Countries Study follow on (1)
- Jay Bhattacharya in conversation with Lord Sumption (1)
- Jebb VS Nutt (1)
- Jimmy Moore on Dr Weil (1)
- John Hawks on Paleo in NY (1)
- Junk Food binge (1)
- Just a heads-up (1)
- Just a little on complex I and models (1)
- Just an announcement (1)
- Just an update (1)
- Kebabs (1)
- Ketoacidotic death in lactation! (1)
- Ketogenic Diet: Eat Food (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe (2) (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe. (1)
- Ketogenic vs moderate carbohydrate diets (1)
- Ketones for ALS? (1)
- Ketones in Tehran (1)
- Ketones without the side order of Danish Pastry please (1)
- Ketones: Should idiots be allowed to write the methods section of any "scientific" paper? (1)
- Ketosis and Protein (1)
- Ketosis links (1)
- Kitava: uric acid (1)
- Kwasniewski and cancer (1)
- Kwasniewski paper (1)
- Kwasniewski; praise the lard (1)
- Lactate as bulk energy transport (1)
- Lard makes hungry mice live longest (1)
- Latest obesity paradox (1)
- Let them eat fat: Ron Rosenbaum (1)
- Life (01) Random musings on carbon monoxide (1)
- Life (02) Polyprenyl derivatives at the origin of life (1)
- Life (03) ATP synthase (1)
- Life (04) On the bench top (1)
- Life (05) Why sodium ions? (1)
- Life (06) What's wrong with sodium ions? (1)
- Life (07) Two timelines (1)
- Life (08) Proto-Ech (1)
- Life (09) Ech (1)
- Life (10) Methyltransferase in methanogens (1)
- Life (11) Ferredoxin (1)
- Life (12) Loki and its membrane potential (1)
- Life (13) Skulachev in 1978 (1)
- Life (14) From Skulachev to LUCA (1)
- Life (15) Skulachev addendum (1)
- Life (16) Mulkidjanian: Na+ pump or Na+/H+ antiporter? (1)
- Life (17) Nick Lane on Proto-Ech (1)
- Life (18) Why stop at formaldehyde? (1)
- Life (19) Metallic iron and the origin of metabolism (1)
- Life (20) How primordial is oxidative phosphorylation? (1)
- Life (21) Pyrococcus furiosus (1)
- Life (22) FeNi hydrogenase (1)
- Life (23) Antiporting: Choose your ion well (1)
- Life (24) Porting over CCCP (1)
- Life (25) Left or right hand? (1)
- Life (26) MrpA MrpD NuoL NuoM and NuoN. Plus nt-Nha. (1)
- Life (27) Alphabet soup (1)
- Life (28) Proton Billiards (1)
- Life (29) Applied billiards to MRP and MBH (1)
- Life (30) Guesses about Na+ channels (1)
- Life (31) Chinese whispers (1)
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26 comments:
Hi Peter. Any chance you'll be posting your slides?
I second that notion: Please post your Powerpoint presentation, Peter.
I was about to ask the same thing!
i am so happy your back!!!
congratulations on presenting.
Mark.
I have another article found as usual, in some shady places 8-:)
If you have an access to the full text it would be interesting to review it:
http://www.ncbi.nlm.nih.gov/pubmed/18804129
"Low-carbohydrate weight-loss diets. Effects on cognition and mood."
Quote:
"The present data show memory impairments during low- carbohydrate diets at a point when available glycogen stores would be at their lowest. A commonly held explanation based on preoccupation with food would not account for these findings. The results also suggest better vigilance attention and reduced self-reported confusion while on the low- carbohydrate diet, although not tied to a specific time point during the diet. Taken together the results suggest that weight-loss diet regimens differentially impact cognitive behavior."
P--
You're such a big THINC-tank!!!!!!!
First lunchin' with Ebringer then the THINC crowd. Next, the world...
-G
Is the THINCS-discussion available on the net? On THINCS.org the discussion ends (unfortunately) Jan-Feb 2006.
Is the THINCS-discussion available on the net? On THINCS.org the discussion ends (unfortunately) Jan-Feb 2006.
True! Unfortunately, THINCS decided to marginalize themselves out of the society by not communicating with the outside world, I no longer look them up since nothing seems to be happening. I find more life, stimulating ideas and science here and on Stephan's blog, then there.
Stan,
Interesting abstract. Since my wife dropped off of PhD time in to extra time from maternity leave, her Athens account has folded so I can't get much in the way of papers. I just pubmeded D'Anci and he has done some very interesting stuff on sucrose augmentation of morphine analgesia.
Isn't Tufts one of the LC hotbeds in the USA?
Slides, I might be able to do something but I never did any speakers notes, so some commentary would be needed, especially on the more abstracted/modified graphs from Keys, Framingham and MRFIT... There's really nothing new unless you are outside the LC world, when old stuff is an eye opener.
Re THINCS, yes there is a lot of off site discussion but very little in public. The base provided by people like Stephan is very broad compared to THINCS, which is quite on topic for a great deal of it's discussions. Very focused but absolutely no Groupthink about what does cause heart disease.
Peter
Lack of Groupthink being an excellent attribute!
Peter
See here for a .pdf copy of "Low-carbohydrate weight-loss diets. Effects on cognition and mood."
Dave,
Thanks for the link to the paper.
I agree that practitioner of low-carb diet will probably endure performance impairment initially.
However, three weeks is hardly sufficient for the brain to switch from glucose to ketones - to draw a conclusion. IMO, it would take at least 10 times longer.
Once the switchover is complete blood sugar will rise to the upper range (due to body's preference for NEFA) and therfore become available for fight/flight response (i.e., any aneaerobic demands.)
Peter,
Welcome back and congratulations on your presentation.
Regarding your low-key, matter-of-fact approach: when the facts are on your side there's no need to pound the table, isn't there?
Hi Dave (and all),
Thanks for the paper. Zero carb and you feel crap.
Now there's a surprise!
Peter
Good to have you back!
Congrats to your wife for finishing up on the PhD. I know how it feels.
Hi Peter, love your blog.
Here's one for future comment, in case you think it is worth comment.
http://www.telegraph.co.uk/scienceandtechnology/science/sciencenews/3346666/Mystery-of-the-meat-eaters%27-molecule.html
Yes you can get your presentation done in 30 minutes or less but you have to write the script first. Remember that if your slides make sense for a person who did not attend the lecture then you are wasting your time giving the lecture.
Read "Beyond Bullet Points" by Craig Atkinson and download the aids of the internet you will find the time well spent.
Hi JMC,
Thanks for the link, a similar article was emailed to me off blog by Taka. My problem with the hypothesis is the pretty ubiquitous meat and dairy consumption in very health long lived non industrialised communities.
Any thoughts on how this might tie in?
I tend to cringe when I read comments about early hominid life being nasty brutish and short. Life for an early hominid was the normal life for a well adapted species in its natural environment. Harmonious is the word which comes to mind. Nasty brutish and short makes me think of life in cotton mills and coal mines!
Peter
Point taken Hermione,
I'm thinking of putting up a section at a time with some explanation attached. The talk dropped in to about 5 sections, some less important than others
Peter
Hi Peter,
I understand what you mean and thanks for taking the time to see this.
A possible (but perhaps neive) explanation is the fact that Vitamin D status since intra-uterine life seems to be more important in auto-immunity development than any other factor. For instance, in countries with year round UVB radiation, there's virtually no Type 1 Diabetes.
Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008 Jun 12.
I think isolating factors doesn't cut it, since the human body is a complex system, where everything is connected and, as you said, all animals thrive best in the environment to which their genes are adapted, which means food, feeding habits (breastfeding, intermittent fasting, etc), sun exposure, exercise, sleep, sex, exposure to pathogens, etc.
This could explain why the Masai are healthy on a high milk and meat diet and the Kitava are healthy on a totally different diet (high carb diet).
Here's some other theory on the subject (health in H/G and in Neolithic people), by Staffan Lindeberg:
Jönsson T, Olsson S, Ahrén B, Bøg-Hansen TC, Dole A, Lindeberg S.
Agrarian diet and diseases of affluence--do evolutionary novel dietary lectins
cause leptin resistance?
BMC Endocr Disord. 2005 Dec 10;5:10
Yes, lectins are probably very important, especially plant derived lectins. You realise that lectins look at sugar moieties and so the lectin hypothesis is not so far removed from the sialic acid derivative hypothesis, the difference being that bulk lectins are neolithic and the Neu5Gc mutation has been around for 3 million years of (variable but on going) meat consumption...
Peter
Peter,
Do you think it's all related to grains?? This Neu5Gc?
All the meat tested in the article that JMC posted appear to be the grain-fed meats ("mystery of the meat...")
--beef, lamb, pork
Like...everything else...
'Those d*mn dirty grains' (and legumes/lectins)!!
-G
Hmmmmm G, you do have to wonder. Another of the problems I have with the hypothesis is that "normal" animals all develop the full range of auto immune diseases that humans do, despite making the enzyme for the final sugar conversion. If this defect is what makes humans prone to auto immune diseases, what right do cats, dogs and horse have getting systemic lupus, haemolytic anaemia and aseptic meningitis? Which they do, I've got some cracking cases on the go at the moment....
I still, probably as you do, keep coming back to plant lectins as being central to these diseases.
Peter
P,
Thanks for your reply.
!!Your inter-animal perspectives are always so INSPIRING and ILLUMINATING.
Yes, lectins/grains have no business in pet food or lab chow!
We really are no different in many respects from our beloved pets. I started taking taurine -- since I don't eat a whole lotta seafood or grassfed meat. Taurine boosts the immune system, lower BP, reduces angiontensin II and acts as a diuretics. BTW it raises HDL, esp synergistically with CLO.
Now, if my cat would die of taurine deficiency, how about humans? Like Scurvy to vitamin C?
HHhhhhhmmmm...
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