Sunday, July 11, 2010

Rimonabant and hemopressin

"All right Mr Bender, before we enrol you in this clinical trial I need to be certain that you do not now, or ever have in the past, partake of any recreational drug, specifically those targeting the CB1 receptors in your brain?"

"Well yeah man, like sure, err, I mean, like no, like what was the question?"

"I'll take that as a no"

"Well sure doc, whatever, like, that's cool. You got something new for me to try?"

"We've developed hemopressin, a totally natural appetite modifying peptide. We don't know where it works in the brain, which neuronal circuits it influences or whether it is safe in humans. We think it's a good idea to give it to you at industrial dose rates which will flood your whole body to boost the micromolar concentrations naturally present in your brain. We think it's harmless and won't produce the depression or suicidal ideation which had Rimonabant withdrawn from the market a few years back. There's a big cheque involved."

"Ok doc, whatever. Like, ok, err, how much did you err like err, um, pay me?"

"My secretary will assist you with completing the deposit slip for your bank account. You do have a bank account?"

"Yeah, well, yeah, well, I can't remember really, did you say bank errr account...?"

"That door there, Mr Bender, the one you came in through."

"Ok, yeah, right"



Two weeks later



"Ah, good morning Mr Bender, a lovely day."

"What's the point? I think I'll just kill myself"

"How is you preoccupation with food?"

"What's the point? I think I'll just kill myself."

"Have you noticed any change in post coital satisfaction?"

"What's the point? I think I'll just kill myself."

"How is your satisfaction rating for visual appreciation?"

"What's the point, I think I'll just kill myself."

"Heard any good bands in the last two weeks?"

"What's the point, I think I'll just kill myself."

"Hmmmmmm. But interest in food is really down, yes?"

"What's the point, I think I'll just kill myself. Oh, Doc, before I go do it, those obese babies in nappies, are they on dope to get that obese? And the fat bankers too, they pot heads too? Never mind. What's the point, I think I'll just kill myself."

"Hmmmmm, partial success with that one I think..."




This post might be less perplexing if you've read this press release about this paper. Hemopressin will bomb like Rimonabant. It's based on the "toxic food environment" hypothesis, which says that the only reason I weigh under 65kg is my diet is too non-hedonistic for me to over indulge in. Conversely a toke of dope should make you obese by rendering the contents of the food aisle of a late night garage in to an hedonistic experience....

BTW, being a good member of law abiding citizenry I have no idea who does or doesn't do dope. But obesity is not a feature of any of the people whom I don't know don't do dope. I've heard about the munchies. I guess dope heads must eat less next day or exercise more, the skinny ones that is....

Peter

OK back to the OD and homocysteine as soon as I can get the next post written. Loads of great links have been emailed to me too, if I could just remember where I left them...

7 comments:

Emily Deans, M.D. said...

While I don't practice there, I have a Texas medical license, and one of the perks is getting a newsletter every year about all the poor souls who lost their medical licenses Usually it is substance abuse of some sort, but two years ago it was some guy who prescribed himself rimonabant off label for weight loss, became psychotic, and apparently scared a bunch of people.

Peter said...

Wow. Yes, it must be very hard sitting in your office with hunger gnawing at your insides by 10.30am while having to lecture poor obese diabetics about how they ate themselves in to diabetes and can starve themselves out of it........ Unfortunately happiness is quite important to humans!

Peter

Ashkiera said...

Oh fun... Another weight loss drug. And those are always harmless. We (my family and I) speculate that my Grandma died from stress on her body from taking too much dexedrine back in the 70's. And then my Mom was put on a "Low Fat" diet because she was overweight and had high triglycerides. She lost weight because she mostly stopped eating. Then she promptly died. She had been relatively healthy when she was FAT.

And now we have another way to kill people early. Population control I guess.

Thank you for your blog. I read nearly everything you write. Though I fear I don't understand all of it... I need a few more biology and chemistry classes.

Gabriel said...

I remember you said you go in and out of ketosis.
How do you define that? I eat about 70-100g of carbs/day and % of total calories is ~15-20%. Would that be considered ketosis? Feel great btw, but I do HIT training everyday.

Peter said...

Hi Gabriel, I pee on a dipstick! If it's faint purple that's the edge of ketosis, I don't do calculations or measure much nowadays.

With HIT everyday you might well need 100g/d of carbs to keep out of frank fasting ketosis.

Hi Ashkiera,

I'm quite interested in the problems of symathomimetics like nicotine and amphetamine. Do the CVD problems associated come from consuming carbs at the same time as forcing lipolysis by stimulating the sympathetic nervous system? Reaven suggests that this may be the way nicotine works. That's ignoring the vasospasm induced by sympathetic stimulants...

Peter

"Guppy" Honaker said...

Food and sex - two of the most enjoyable, and problematic, issues of our day. I have always been skinny all of my life. Doing everything I could to gain weight. Now I'm in my 50's, and work to keep the weight off! (But no drugs for this boy. I prefer self-control over dangerous chemicals)

- David

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"Guppy" Honaker said...

PS: I tried "pot" twice in my teenage years. Didn't do anything but it does stink. Happily, never tried it again.