Well that's me back from the AVA meeting in Liverpool. Highlights: Arterial blood gas sampling at the top of Everest, all rough quotes from memory:
"The peak was a bit 'peakier' that we had anticipated so we dropped down a few hundred feet to a more level patch before dropping out trousers in a 20 knot breeze at -24degC to stab each other's groins for arterial blood samples".
Getting to the top of Everest? "I never train" linked to "it's all mitochondrial" and "Ground level athletes really struggle on the big mountains, Ranulf Fiennes took three attempts to get to the top and it was very hard for him".
Reinhold Messner is STILL ALIVE (obviously he has remarkable mitochondria). OMG I thought he'd have made a single small mistake at some point before now. Having read some of his earlier achievements I'd never expected him to make old bones. But he must be older than me...
And the RN battlefield anaesthetist from Iraq/Afghanistan. "These guys come in needing one, two or even three amputations from an environmental temperature at up to 40 degC. One of the worst prognostic markers is hypothermia. We think it's mitochondrial".
A good friend (with an excellent brain, yes she has already read Power Sex and Suicide while moving from anaesthesia to obesity research) chatting about DMT2 in horses "It's all mitochondrial".
One of her co-workers on cartilage degeneration in arthritis "It's all mitochondrial".
I had a great meeting.
I got, without net access, to read through and analyse some of the implications of the downloaded papers on mitochondrial dysfunction in obesity from JS's page on metabolic flexibility. Needless to say these links are good but you HAVE to read the papers, follow the secondary links then read the methods. Needless to say there is a lot to say and I'm still not about to go carb loading.
Time to get the Baba-breakfast ready. I'll try to get to emails and read comments over the w/e, but life really is very busy.
Quote of the century: "It's all mitochondrial".
Oh, and it's not quite as simple as failure to burn fat.