Over the years I have read some pretty far out stuff. I think I've commented previously on the late Dr Abram Hoffer's use of B3 for controlling schizophrenia. Interesting and a source of thought trains which I never got the time to follow through. What I personally enjoyed were the accounts of recovered schizophrenics as to what it was like to have been inside the syndrome and then recover. Re-reading the site, it all looks very anecdotal now.
I also went so far as to purchase his book, written in conjunction with Linus Pauling, on treating cancer with vitamins B3 and C. You can just google the ISBN number 18970251141897025114 to find out a bit more about it. I see it's quite financially valuable nowadays!
Before we settle down to the nuts and bolts of the deeply involved models which the latest complex I paper (thanks George) used, the bottom line is that adding 1% nicotinamide (similar effects could be obtained with vitamin B3) to the mouse breast cancer models was very impressive at extending lifespan of those mouse models, especially through suppression of metastasis.
I find this slightly eerie. I can hear Hoffer in my head, sounding rational and being regarded as a quack for treating cancer (and many other illnesses including schizophrenia) with B3. Yet here are these guys in 2013 with their multiple mouse models, multiple tumour types, multiple interventions all showing that B3 or its analogue is very, very effective in suppressing breast cancer metastasis. In mouse models of course.
Slightly déjà vu...
A lot more to say about this paper but the B3 aspect is just so weird I had to put this aside up.