Well, here I am briefly. Things have pretty much ground to a halt on Hyperlipid. What has happened is that my boss has broken his little finger, in to lots of little pieces (pushbiking is pretty dangerous!). The steel pin, support dressing and full time sling don't seem to be doing much good so he's off work for 6 weeks and I've gone from working one day a week to working full time. Then our other primary surgeon is on study leave for his surgery ticket and our full time internal medicine slanted vet is off sick... So this is the first time I've logged on to do anything other than check work emails.
I'm just finishing week four out of six... By the time I get to answer comments people will probably will probably have forgotten they posted them! Still, it pays off a chunk of the mortgage.
So apologies for the lack of activity and replies.
BTW the off sick vet is really interesting. Anaemia to the point of hyperventilation after climbing the stairs and recurrent major infections. Ah, Weight Watchers and wholemeal bread! People love these wacky diets, play at your own risk!
Peter
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You need to get calories from somewhere, should it be from carbohydrate or fat?
About Me
- Peter
- I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
Organisation (or lack of it)!
The "labels" function on this blog has been used to function as an index and I've tended to group similar subjects together by using labels starting with identical text. If they're numbered within a similar label, start with (1). The archive is predominantly to show the posts I've put up in the last month, if people want to keep track of recent goings on. I might change it to the previous week if I ever get to time to put up enough posts in a week to justify it. That seems to be the best I can do within the limits of this blogging software!
Blog Archive
Labels
- !Kung Bushmen and mongongo nuts again (1)
- !Kung Bushmen and mongongo nuts yet again (1)
- A aargh BROKEN LINKS (1)
- A bit more on ketones and diabetic nephropathy (1)
- A brief aside in to statins and FH and all cause mortality (1)
- A brief discussion of ketosis (1)
- A defect of fat metabolism and a few thanks (1)
- A glimmer of light (1)
- A heads up (1)
- A little more on PCSK9 inhibitors (1)
- A load of crap in Gartnavel (1)
- A Peek at Paleo (1)
- A post not about Walter Kempner (1)
- A tale of two abstracts (1)
- A wander off in to dietary protein calories (1)
- ACCORD and musings on insulin (1)
- Acetoacetate and arterial oxygen tension (1)
- Acetone to oxaloacetate (1)
- Acipimox (2) and weight gain (1)
- Acipimox and insulin (1)
- Acipimox and insulin action (1)
- Adipose triglyceride lipase knockout mice (1)
- Adipotide and the Bad Fat (1)
- Adrian Ballinger on Everest (1)
- AGE RAGE and ALE (1): The AGE of LDL (1)
- AGE RAGE and ALE (2): The ALE of LDL (1)
- AGE RAGE and ALE (3): oxLDL (1)
- AGE RAGE and ALE (4): segregation (1)
- AGE RAGE and ALE (5): fasting (1)
- AGE RAGE and ALE (6): low fat (1)
- AGE RAGE and ALE (7): VLDL degradation (1)
- AGE RAGE and ALE (8): VLDL degradation and Krauss (1)
- AGE RAGE and ALE (9): VLDL degradation and Fish Oil (1)
- AGE RAGE and ALE posts (10): small dense Krauss (1)
- AGE RAGE and ALE posts (11): linoleic acid (1)
- AHA approved egg! (1)
- Alcohol and fructose are the same to your liver (1)
- Alcohol and weight loss (1)
- Alzheimer's (1)
- Alzheimers and ketones (1)
- Alzheimers and omega 6s (1)
- Alzheimers and Tau proteins (1) (1)
- Alzheimers and Tau proteins (2) (1)
- Amgen share price and PCSK9 inhibition with Repatha (1)
- Amgen share price and PCSK9 inhibition with Repatha (2) (1)
- an aside (1)
- An aside on psychiatric links from Sid Dishes (1)
- An embarrassment of cress (1)
- An Error (1)
- An exchange of half bricks (1)
- Anacetrapib and phytotoxins (1)
- Anger vs diet in Japan (1)
- Animal fat and cholesterol (1)
- ARDS and linoleic acid (1)
- ARDS and Tucker Goodrich (1)
- ARDS isoprostanes and isofurans (1)
- Are COVID-19 vaccines useful? (1)
- Are COVID-19 vaccines useful? (2) (1)
- Are COVID-19 vaccines useful? (3) (1)
- Are humans just multicellular yeasts? (1)
- Are ketone esters dangerous? (1)
- Are you lino-philic? (2) (1)
- Are you on clenbuterol? (3) (1)
- Are you trans-phobic? (1) (1)
- Arteriosclerosis (1) in 1957 (1)
- Arteriosclerosis (2) and sulphation factor (1)
- Arteriosclerosis (3) and von Willebrand Disease (1)
- Arteriosclerosis (4) GAG and sudden death (1)
- Arteriosclerosis (5) GAG and sudden death part two; the pictures (1)
- Arteriosclerosis (6) and Subbotin (1)
- Arteriosclerosis and saturated fat (1)
- Arteriosclerosis and the breeder rat (1)
- Arteriosclerosis images (2): Models (1)
- Athletic acid reflux (1)
- Atrial tachycardia and fibrillation (1)
- Axen and Axen (1) (1)
- Axen and Axen (2) (1)
- Axen and Axen (3) Hawks (1)
- Axen and Axen (4) Ketogenic insulin resistance. It's all over now... (1)
- Axen and Axen (5) The tradition continues (1)
- Back on line (2)
- Back to a semblance of normality: A couple of conversations (1)
- BAM15 and semaglutide are not insulin sensitising (1)
- Barja (1)
- Best ever statin study comment? (1)
- Best ever statin study? (1)
- Beta oxidation intermediates control ETC function (1)
- Blood "energy" content (1)
- Bob Michell on meta-analysis (1)
- Boiled mashed potatoes for miracle weight loss? (1)
- Boxes (1)
- Brain on a statin (1)
- Brain on chocolate (1)
- Brand insights (1)
- Brand on 4-HNE facilitated uncoupling (1)
- Breast cancer and starch (1)
- Breast cancer BRCA1 and metabolic syndrome (1)
- butter and leptin receptors: Speculation! (1)
- Butter gives you fatty liver! Again. (1)
- Butter insulin and Dr Davis (1)
- Butter vs peanut butter (1)
- Can linoleic acid keep you slim? (1)
- Cancer and ketones (1)
- Cardiac ischaemia and low carbohydrate diets (1)
- Casein and gluten and gastric pH (1)
- Casein vs gluten (1)
- Cat rawfeeding; scroll down the comments (1)
- Cell surface oxygen consumption (1) (1)
- Cell surface oxygen consumption (2) (1)
- Cell surface oxygen consumption (3) (1)
- Cell surface oxygen consumption (4) Influenza (1)
- Chicken fillets are not meat. If you're a cat. (1)
- Cholesterol (the HDL sort) kills? (1)
- Cholesterol and Carruthers (1)
- Cholesterol and cholestyramine (1)
- Cholesterol and heart attack survival (1)
- Cholesterol and innate immunity (1)
- Cholesterol and memory (1)
- Cholesterol and Son of J-LIT (1)
- Cholesterol and the J-LIT study (1)
- Cholesterol and the J-LIT update (1)
- Cholesterol fed rabbit (1)
- Cholesterol heart attacks and JUPITER (1)
- Cholesterol hypothesis in 2010 (1)
- Cholesterol hypothesis in 2010 part 2 (1)
- Cholesterol JUPITER link (1)
- Cholesterol Milano style (1)
- Cholesterol pacitimbe and ACAT (1)
- Cholesterol presentation: Between countries (1)
- Cholesterol ratios through the looking glass (1)
- Cholesterol ratios: Torcetrapib again (1)
- Cholesterol reflectivity at 400nm (1)
- Cholesterol within nations studies (1)
- Cholesterol; it's not a competition (1)
- Cholesterol; MESA and EBCT (1)
- Cholesterol; statins kill? (1)
- Cholesterol: ASTEROID destroys lipid hypothesis (1)
- Cholesterol: Do chylomicrons clog your arteries? (1)
- Cholesterol: Do chylomicrons clog your arteries? (2) (1)
- Cholesterol: LCAT and rabbits (1)
- Cholesterol: LDL in Oslo (1)
- Cholesterol: More epidemiology (1)
- Cholesterol: Near miss in Edinburgh (1)
- Cholesterol: Peto seeing some light? (1)
- Cholesterol: statins and oxLDL (1)
- Choose your insulin sensitivity well (1)
- Cirrhosis and corn oil (1)
- Cirrhosis and fish oil (1)
- Cirrhosis and fructose (1)
- Clofibrate and PUFA (1)
- Coconut oil and obesity (1)
- Coconuts and Cornstarch in the Arctic? (1)
- Coffee (1)
- Colorectal cancer and cholesterol (1)
- Colorectal cancer; fiber and the PPT (1)
- Complex I: Hoffer and B3 (1)
- Complex IV and control of delta psi (1)
- Conditioning Research on bad carbs (1)
- Confirmation Bias in my head (1)
- Confirmation bias is not just in my head (1)
- Confirmation bias is so nice (1)
- Coronary Artery Calcium Score and Scleroderma (1)
- Coronavirus is possibly everywhere (1)
- Costa del Glasgow (1)
- Covid playground (1)
- COVID-19 (1)
- CPT1aL479 resurfaces nicely (1)
- Crabtree and cardiovascular surgery (1)
- Credo (1)
- Cynthia Kenyon link (1)
- Dave Asprey and Dr Veech (1)
- David Blaine and refeeding syndrome (1)
- Dead people DO bleed... (1)
- Death by dogma (1)
- Delta psi and insulin and ROS (1)
- Delta psi and ROS (1)
- Denmark purchased using Flora profits? (1)
- Deuterium protected linoleic acid (1)
- DHA in rats (1)
- Diabetes and cardiac apotosis (1)
- Diabetes and hunger (1)
- Diabetes in Sweden (1)
- Diabetes in Sweden update (1)
- Diabetes; endothelial damage (1)
- Diabetic and hungry? (1)
- Diabetic nephropathy and the lost Swede (1)
- Diagnosing and Treating Vitamin B12 Deficiency Video (1)
- Do you believe in MRI scanners? (1)
- Dodgy D'Anci (1)
- Double Bond Index and longevity in humans (1)
- Dr Davis links (1)
- Dr Doug Wallace on mitochondria (1)
- Dr Ravnskov on statins for primary prevention of CVD (1)
- Dr Uffe Ravnskov MD PhD interview (1)
- Dr Wolfgang Lutz Obituary (1)
- Dunnigan Familial Partial Lipodystrophy (1)
- Earning a crust (1)
- Easiyo (1)
- Eat as much starch as you wish (1)
- Eating lots of meat and nothing much else (1)
- EBCT scan (1)
- EFA deficiencies? (1)
- Eggs are here (1)
- Eggs in Ontario (1)
- Electrochemistry (1)
- Electrochemistry (2) Superoxide (1)
- Electron Transport Chain image (1)
- Endocannabinoids in brain and adipocytes (1)
- Endotoxin Absorption on a High Fat Diet (1)
- Endurance and oxygen flux during fatty acid oxidation (1)
- Energy expenditure in obese vs slim non dieters (1)
- EPIC HbA1c and heart attacks (1)
- Essential fatty acids are essential (1)
- Excession (1)
- Faking it with selenium (1)
- Familial Hypercholesterolaemia (1)
- Familial Hypercholesterolaemia and glucose (1)
- Familial Hypercholesterolaemia and porcelain (1)
- Familial Hypercholesterolaemia Brown and Goldstein (1)
- Familial Hypercholesterolaemia heterozygous survival (1)
- Fancy some serology? (1)
- Fancy some serology? (2) (1)
- Fancy some serology? (3) In Japan (1)
- Fasting insulin and weight loss (1)
- Fasting insulin and weight loss and calories-in vs calories-out (1)
- Fasting insulin and weight loss on a water fast (1)
- Fat storage and retrieval (1)
- Fathead Supersize Me and Sweden (1)
- Fathead Supersize Me and Sweden (2) (1)
- Fats and absorbing endotoxin (1)
- Feeling experimental? (1)
- FFA vs 4-HNE for activating uncoupling (1)
- Fiaf (1) Who's fat is it anyway? (1)
- Fiaf (2) starving amidst plenty (1)
- Fiaf (3) where next? (1)
- Fiaf (4) memes and fat (1)
- Fiaf (5) Meme Watching (1)
- Fiber inulin and cancer (1)
- Fiber sucrose and ulcers (1)
- FIP vaccines etc (1)
- FIRKO mice (1)
- FIRKO-isation without all the hassle? (1)
- FIRKO-ise (1)
- First meat (1)
- Flow Mediated Dilation: What does it mean? (1)
- Foie Gras (1) Peroxisomes (1)
- Foie Gras (10) Liver (1)
- Foie Gras (11) Hepatocyte mitochondria (1)
- Foie Gras (2) Lard fed rats (1)
- Foie Gras (3) carbohydrate (1)
- Foie Gras (4) RER (1)
- Foie Gras (5) An aside on how to stay slim (1)
- Foie Gras (6) inflammatory mRNAs (1)
- Foie Gras (7) What do you mean by inflammation? (1)
- Foie Gras (8) Vaughan's macrophages (1)
- Foie gras (9) Adipocyte ROS (1)
- Foie gras from safflower oil hiatus (1)
- Folate and homocysteine (1)
- Follow on to Tucker's post on PUFA in rats (1)
- Food fermented cream (1)
- Food; carnitas (1)
- Food; chicken salsa (1)
- Food; Mutton followed by cheesecake (1)
- Food; sausages (1)
- Food; steak and kidney casserole (1)
- Food: African Beef Stew (1)
- Food: Burgers (1)
- Food: Lardo; the real thing (1)
- Food: Liver and bacon (1)
- Food: Liver; can you over do it? (1)
- Food: Mutton or lamb in orange sauce (1)
- Food: Offal (1)
- Food: Optimal ice cream (1)
- Food: Pork in green salsa and random dessert (1)
- Food: Recipe group (1)
- Food: steak and kidney casserole (1)
- French paradox in Sweden (1)
- From Yeasts to Chloroquine (1)
- Fructose (01) There's a signal (1)
- Fructose (02) Obesogen (1)
- Fructose (03) NOX vs RET (1)
- Fructose (04) Normal Adults (1)
- Fructose (05) Four out of five diabetics (1)
- Fructose (06) Acipimox tangent (1)
- Fructose (07) Acipimox tangent II (1)
- Fructose (08) Acipimox and FFAs (1)
- Fructose (09) The Surwit hepatocyte (1)
- Fructose (10) A can of cola (1)
- Fructose and gout (1) (1)
- Fructose and gout (2) (1)
- Fructose and heart attacks (1)
- Fructose and lactic acid in Naked Mole Rats (1)
- Fructose and leptin (1)
- Fructose and lipolysis (1)
- Fructose and metabolic syndrome: Uric acid (1)
- Fructose and triglycerides (1)
- Fructose Glucose and Cholesterol (1)
- Fruit and vegetables (1) cause DNA damage (1)
- Fruit and vegetables (1) re post (1)
- Fruit and vegetables (10) WHI and cancer (1)
- Fruit and vegetables (11) link (1)
- Fruit and vegetables (12) WHEL and CVD (1)
- Fruit and vegetables (13) become eggs (1)
- Fruit and vegetables (14) Listeriosis is no fun (1)
- Fruit and vegetables (2) damage your DNA... latest study headline (1)
- Fruit and vegetables (3) last post (almost) (1)
- Fruit and vegetables (4) The asterisk (1)
- Fruit and vegetables (5) in Holland (1)
- Fruit and vegetables (6) WHEL study (1)
- Fruit and Vegetables (7) Mediterranean France (1)
- Fruit and vegetables (8) WHEL study and McDougall (1)
- Fruit and vegetables (9) potato fruits (1)
- Fruit Flies and NDI1 (1)
- FSA apple (1)
- FSA in Glasgow (1)
- Full blown linoleic acid deficiency: speculation (1)
- Getting fat (1) staying fat (1)
- Getting fat (2) staying fat; follow on (1)
- Getting fat (3) is good (1)
- Getting fat (4) is bad when you stop (1)
- Getting fat (5) Hunger (1)
- Getting fat is good (6) Official (1)
- GLP-1 agonists (1)
- Glucosamine and aged mice (1)
- Glucose as a cure for hypertriglyceridaemia? (1)
- Glucose from fatty acids: RQ of 0.454 (1)
- Glucose lactate and cancer (1)
- Gluten and cardiomyopathy (1)
- Gluten and gall bladders (1)
- Gluten and NK cells (forget the antibodies) (1)
- Gluten and rheumatoid arthritis (1)
- Gluten and schizophrenia SPECT scan (1)
- Gluten ataxia (1)
- Gluten coeliac and multiple sclerosis (1)
- Gluten Dr Briffa link (1)
- Gluten links from Bloggeier (1)
- Gluten poppy pictures (1)
- Gluten-Congratulations: You have coeliac disease (1)
- Gluten; thyroid and auto immunity (1)
- Gluten: Does coeliac disease require an infection? (1)
- Gluten: Not your average plant toxin? (1)
- Gluten: The NICE guidelines for UK diagnosis (1)
- Glycaemic load and breast cancer (1)
- Gourmand Rats? (1)
- Great Barrington Declaration (1)
- Great Barrington Declaration (2) (1)
- Green Tea Extract; superb antioxidant? (1)
- GSD IIIa ketones MAD and Veech again (1)
- GSD type I vs GSD type III: Cornstarch vs ketones (1)
- Guddling in the dark (1)
- Guddling in the dark for a respiratory quotient (2) (1)
- Guess the weight of the mouse competition (1)
- Gwyneth Paltrow has osteopaenia (1)
- Hall and CICO again (1)
- Hall and CICO part 2 (1)
- Hall and CICO part 3 (1)
- Have you thought about electron transporting flavoprotein dehydrogenase and its substrate electron transporting flavoprotein? (1)
- Hazel eats butter (1)
- HbA1c and Familial Hypercholesterolaemia (1)
- HbA1c: Crack vs smack for a lower reading? (1)
- HbA1c: Low glucose and acid (palmitic) (1)
- Heart failure and insulin resistance (1)
- Helicobacter and glucose (1)
- Helicobacter and hydrogen (1)
- Hepatic extraction of fructose (1)
- Hepatic insulin resistance (1)
- Hepatic insulin resistance in KD fed mice (1)
- Hepatic insulin resistance through caloric overload (1)
- Here we go in to Lockdown 2 (1)
- Heroin and IBS (1)
- High fat diet and fertility (1)
- High fat diets make you fat and stupid (1) (1)
- High fat diets make you fat and stupid (2) (1)
- High fat Dutch style (1)
- High fat fed mice on stearic acid (1)
- High fat meal is analgesic (1)
- HLA-B27 and Ebringer (1)
- HLA-B27 and Ebringer BSE text (1)
- HLA-B27 and Ebringer speech text (1)
- HLA-B27 some more (1)
- Holiday reading (1)
- How can insulin resistance cause weight gain? (1) ALDH2 (1)
- How can insulin resistance cause weight gain? (2) 0.1 μM (1)
- How can insulin resistance cause weight gain? (3) AD-9308 (1)
- How can insulin resistance cause weight gain? (4) amplification (1)
- How can insulin resistance cause weight gain? (5) MCTs (1)
- How incomplete was LUCA? (1)
- HOW MANY bananas a day? (1)
- How many eggs per day? (1)
- How much linoleic acid to get fat and insulin resistant? (1)
- How toxic is wheat? (1)
- How's it going (1)
- Hunting gathering and starving (1)
- Hyperglycaemia and free radicals (1)
- Hyperglycaemia is bad (1)
- Hyperlipid Protons ambassadors (1)
- I'm back (1)
- If there were time... (1)
- IgG IgA and sniffing a virus (1)
- IgG IgA and sniffing a virus which stinks (1)
- IHD and ghee (1)
- IHD single vessel disease (1)
- IHD Tracking plaque 1950s style (1)
- Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state (1)
- In the gym (1)
- Inhibiting lipolysis using acipimox (1)
- Insulin and confusion (1)
- Insulin and the Rewards of overfeeding (1)
- Insulin detemir (1) (1)
- Insulin detemir (2) (1)
- Insulin detemir (3) (1)
- Insulin glucagon and protein (1)
- Insulin in the brain: Hyperphagia? (1)
- Insulin in the brain: off topic giggle (1)
- Insulin increases coupling in mitochondria (1)
- Insulin makes you hungry (1) (1)
- Insulin makes you hungry (10) Processing (1)
- Insulin makes you hungry (2) even in the presence of hyperglycaemia (1)
- Insulin makes you hungry (3) a matter of semantics and free fatty acids (1)
- Insulin makes you hungry (4) unless you keep it out of your brain (1)
- Insulin makes you hungry (5) except when you resist (1)
- Insulin makes you hungry (6) except when you snort it (1)
- Insulin makes you hungry (7) superoxide is satiety (1)
- Insulin makes you hungry (8) Blokes (1)
- Insulin makes you hungry (9) Women (1)
- Insulin mimesis and NOX enzymes (1) A principle (1)
- Insulin mimesis and NOX enzymes (2) Lactate (1)
- Insulin mimesis and NOX enzymes (3) MCT (1)
- Insulin mimesis without NOX enzymes (4) MCT (1)
- Insulin mimesis without NOX enzymes (5) MCT plus linoleic acid (1)
- Insulin mimesis without NOX enzymes (6) MCT versus linoleic acid (1)
- Insulin sensitivity makes you fat (1)
- Insulin sensitivity makes you fat: growth hormone receptor deletion (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (02) (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (03) Visceral vs subcutaneous (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (04) M scores (1)
- Insulin; the Un-dead and coffin nails (1)
- Insulin: Are you hungry? (1)
- Insulin: Are you hungry? Part 2 (1)
- Insulin: The Flatline Days (1)
- Intellectual honesty vs obfuscation (1)
- Interesting times on Mars (1)
- Intimal wall volume reductions with weight loss (1)
- Is the astrocyte-neuron lactate shuttle finished? (1)
- Is vaccine efficacy a statistical illusion? (1)
- It's never too late to normalise your glucose (so long as you are still alive) (1)
- Jan Kwasniewski comment (1)
- Japan and a Seven Countries Study follow on (1)
- Jay Bhattacharya in conversation with Lord Sumption (1)
- Jebb VS Nutt (1)
- Jimmy Moore on Dr Weil (1)
- John Hawks on Paleo in NY (1)
- Junk Food binge (1)
- Just a heads-up (1)
- Just a little on complex I and models (1)
- Just an announcement (1)
- Just an update (1)
- Kebabs (1)
- Ketoacidotic death in lactation! (1)
- Ketogenic Diet: Eat Food (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe (2) (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe. (1)
- Ketogenic vs moderate carbohydrate diets (1)
- Ketones for ALS? (1)
- Ketones in Tehran (1)
- Ketones without the side order of Danish Pastry please (1)
- Ketones: Should idiots be allowed to write the methods section of any "scientific" paper? (1)
- Ketosis and Protein (1)
- Ketosis links (1)
- Kitava: uric acid (1)
- Kwasniewski and cancer (1)
- Kwasniewski paper (1)
- Kwasniewski; praise the lard (1)
- Lactate as bulk energy transport (1)
- Lard makes hungry mice live longest (1)
- Latest obesity paradox (1)
- Let them eat fat: Ron Rosenbaum (1)
- Life (01) Random musings on carbon monoxide (1)
- Life (02) Polyprenyl derivatives at the origin of life (1)
- Life (03) ATP synthase (1)
- Life (04) On the bench top (1)
- Life (05) Why sodium ions? (1)
- Life (06) What's wrong with sodium ions? (1)
- Life (07) Two timelines (1)
- Life (08) Proto-Ech (1)
- Life (09) Ech (1)
- Life (10) Methyltransferase in methanogens (1)
- Life (11) Ferredoxin (1)
- Life (12) Loki and its membrane potential (1)
- Life (13) Skulachev in 1978 (1)
- Life (14) From Skulachev to LUCA (1)
- Life (15) Skulachev addendum (1)
- Life (16) Mulkidjanian: Na+ pump or Na+/H+ antiporter? (1)
- Life (17) Nick Lane on Proto-Ech (1)
- Life (18) Why stop at formaldehyde? (1)
- Life (19) Metallic iron and the origin of metabolism (1)
- Life (20) How primordial is oxidative phosphorylation? (1)
- Life (21) Pyrococcus furiosus (1)
- Life (22) FeNi hydrogenase (1)
- Life (23) Antiporting: Choose your ion well (1)
- Life (24) Porting over CCCP (1)
- Life (25) Left or right hand? (1)
- Life (26) MrpA MrpD NuoL NuoM and NuoN. Plus nt-Nha. (1)
- Life (27) Alphabet soup (1)
- Life (28) Proton Billiards (1)
- Life (29) Applied billiards to MRP and MBH (1)
- Life (30) Guesses about Na+ channels (1)
- Life (31) Chinese whispers (1)
- Life (32) On the correct side of the fence (1)
- Life (33) Transient hunger (1)
- Life (34) Complex I pumping (1)
- Life (35) NiFe pumping (1)
- Life (36) Complex I. Protons are large (1)
- Life (37) Just a gif of complex I (1)
- Life (38) Water Wires (1)
- Life (39) NuoH (1)
- Life (40) Proton pumping (1)
- Linoleic acid and Tuberous Sclerosis (1)
- Linoleic acid makes you hungry (1)
- Linoleic acid panel discussion (1)
- Lipid blockage (1)
- Lipoprotein(a) a prickly subject (1)
- Lipoprotein(a) and ascorbate (1)
- Lipoprotein(a) and DELTA (1)
- Lipoprotein(a) and genetics (1)
- Lipoprotein(a) and oxidised cholesterol (1)
- Lipoprotein(a) and oxidised lipids: What's your mimium requirement? (1)
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37 comments:
Hi Peter,
i need to lose weight i weigh 300 lbs at 5 feet 10 inches i wat it to be high in fat 70 or 80% to get my insulin down.I know to much protien turns in to insulin so i want to keep it high fat.I just bought organic cold pressed coconut oil and i love butter and eggs and bacon ant suggestions.
thanks Bill
Hello Peter,
I read an article in a veterinary periodical that claims vets have a higher suicide rate than MDs or dentists. Your sickly colleague reminded me that stress causes a lot of disease as well as presaging suicide. Probably we vets have better access to euthanasia solution than other medical types. In my state, wyoming, we also have easier access to handguns.
Kevin
Ah, just a couple more weeks; the end is in sight. We're all (I assume you too) looking forward to having you back.
Peter,
We all miss you...take as easy as you can....is great that you are able to fill in for your colleague.
Take care,
Hela
Bill, you might want to try out the naturally refined coconut oil. It's usually just melted and filtered by fuller's earth or clay. Ray Peat is one of the authorities / proponents of coconut oil and he has seen that unrefined/virgin oils often cause a problem (allergy, hypoglycemia, and intestinal problems). He suggests a coconut oil refined the traditional way by filtration. Spectrum Refined is an acceptable brand in the USA. Otherwise, just look for "76 degree Coconut Oil" as cheap as possible. It should have a clean fresh taste, not a smoky, burnt, or disgusting taste. Here's an article by Ray on coconut oil.
http://raypeat.com/articles/articles/coconut-oil.shtml
Other fats I would suggest are mac nut oil, cocoa butter, ghee, kidney suet, pork leaf fat, etc. They are all very low in PUFAs, whereas most vegetable oils are very high and I would avoid them totally.
http://raypeat.com/articles/articles/fats-degeneration.shtml
Hi Bill,
The approach I use is outlined in some detail here. You may want to back off a little on the amount of fat and remember that JK's ideal weights will be higher than many people want.
Just choose the ratios for weight los, fix yourself up with a Fitday account and you're away.
Peter
Thanks Peter, I just wanted to see your view of it, none-the-less I think you are right about following the OD...hope you are having a restful Sunday.
Hela
Hi Kevin,
Yes, I think I've read the same. Hopefully she'll stop WW soon and get on with regaining the transient weight loss it produces. At least this will get some nutrients on board. Hope so.
Peter
Cardimom, Hela and Chainey,
I've taken some tips from Stephan about ecodriving and use the hour and a half each day in the car as a time to listen to music and chill. The biggest stress is probably on my wife as I'm away just after 7am and often not back until between 8 and 10pm, so she does most of the Squigg work as well as being well in to the third year of her PhD. In her copious spare time she's started writing up her thesis and has begun a novel! That's what comes of being a workaholic and having a supervisor who teaches creative writing on her days off...
Thanks for your thoughts,
Peter
PS Chainey; why do you keep taking your blog down? It's on my bookmark list alongside Cardimom's
Hela,
Today has been a total family day. Just great. Tidied the garden, fed the ducks on the village pond, been to the park, picnic in Newbury. Squiggs watched a narrowboat come through the lock in central Newbury and was fascinated. Just a good day. Having a brief catch up here while supper cooks... We've grown some tomatillos so it's chicken in green salsa, first of the crop tonight.
Peter
kevin - It could also be that individuals who are interested in medicine BUT with mental illnesses may be more inclined toward veterinary school than medical school or dentistry.
For some people, an underlying mental problem may have symptoms like being intolerant of working with humans; if this individual was medically inclined, naturally they would choose to become an animal doc instead of working more closely with people.
I don't mean to imply that vets are antisocial or crazy! I just meant to say that people who have emotional problems may push them toward vet school instead of working with people. I only thought of this because I myself considered working with animals for precisely these reasons, lol.
It's kind of like how mental health workers are notorious for having their own difficulties... a person's profession says a lot about their personality, and being very interested in animals may be a marker for emotional issues that make working with people difficult.
(BTW, in spite of an interest in medicine/health and difficulty with socialization...I finally decided to go to nursing school. Yea, I must have been on crack. If this doesn't work out because of the people thing, my next career might be... vet tech!
I would probably make a better kitty/doggy nurse than a human one. I love animals and find it very easy to deal with them.
I only didn't consider the job because I assumed they must make minimum wage. When I found out vet techs make 20+ per hr I felt like a big idiot for not considering it earlier.
Glad to hear that you had sometime for you and your family...feeding the ducks is so much fun, I lived in Florida right by a lake and used to feed every afternoon lots of ducks(they were there always on time...5:00pm in the summer and 3:00 pm in the winter). Your wife is amazing to be able to do a PhD and take care of Squiggs...being a mother of an 11 month old baby girl, I can testify that is not a trivial job...I can tell you that she must miss your company and help, it is a big help having your husband home.
Anyway, it seems like you were able to recharge energy this weekend.
Hi Peter,
It is said that we need extra salt to digest cooked meat / protein.
I don't know for shore and when I ask others some believe we need salt but don't know for shore. Those following a raw meat diet claim that salt is not needed.
How do animals on a natural diet of raw meat make hydrochloric acid?
Nicola
Switzerland
Nicola,
I'm not really sure where the question comes from. As I understand it the enzyme carbonic anhydrase splits H2CO3 in parietal cells to give a bicarbonate ion (which ends up in the plasma pool in exchange for a chloride ion) and an H+ ion which is pumped in to the gastric lumen with the Cl- ion. The bicarbonate ion, as NaHCO3, is used to neutralise the HCl in the small intestine giving NaCl. NaCl is easily absorbed from the intestine. I can see no net loss of sodium or chloride here. So is the cooked meat supposed to be doing something to this cycle which raw meat doesn't?
Beyond me.
BTW extracellular fluid is sodium and chloride rich, there is a fair amount in meat, especially if you drink the gravy. Our kidneys have phenomenal powers of sodium retention on a zero added salt diet. Serious sodium disturbance is fatal. I spend half my life pouring salty water of assorted compositions in to the veins of patients in which the control system has gone wrong for various reasons.
Peter
Fair enough Chainey!
Peter
Chainey said...
ITW: It may be different in other parts of the world, but here in NZ it's exceptionally difficult to become a vet. The places in university are oversubscribed several hundred percent every year so they only take the cream of the students.
While in college we were told the same thing, that there were 10 applicants for every seat in the vet medical school. The fallacy is that every failed medical, dental and chiropractic student also applies to vet medical school as a back-up. The admissions office spent most of their time weeding out dilettantes. One method was giving applicants a tour and showing them students doing rectal exams on cattle. When I was in vet school a tour got to see me cutting a dead calf out of its mother. It had been dead several days and maggots were crawling everywhere...on me, in my hair...
Hello Peter,
The real human diet is a totally carnivorous one...but when it comes to salt?
http://tinyurl.com/6kouyp
http://tinyurl.com/589yul
Do you believe/know if raw or cooked meat needs extra salt for our body to produce hydrochloric acid and meet all body needs?
Nicola
I would agree that it is possible to be healthy eating a totally carnivorous diet but I personally doubt very much that it has been the pattern for humans world wide.
To reject vegetable food complepetely would be too wasteful of available resources. This seems as contrarian as the vegan approach, except the full vegans do not seem to be healthy long term (not that I know any) unless they supplement, where as full carnivory allows this.
Re salt, digestion cycles salt. Those who suggest cooking increases total body salt requirement need a mechanism. Without that it smells like religion to me. Full carnovores are perfectly well able to extract the 160mmol of salt from extracellular fluid and a few more mmol from intracellular fluid. Zero sodium urine is well within the ability of humans, dogs and cats.
Where is the physiology to base the discussion around?
Peter
Hi Peter.
I know I'm probably OT here, but I'd like to ask you a question
with regard to the relationship between cancer and glucose. I've read somewhere glucose has a very similar molecular structure than Vitamin C and this is the reason for many low-carbers to say vitamin C needing is lesser on a LC diet. I'm not trained in molecular biology but could it happen that cancer cells, in their needing for glucose, try to metabolize (BY MISTAKE) Vitamin C molecules, with the consequence of large developement of hydrogen peroxide, TOXIC to them, and maybe less production of glucose via gluconeogenesis? I don't know whether a study combining an EXTREME low-carb diet with large amount of Vitamin C has ever done.
Or maybe they've done a lot of study about cancer and vitamin C, or about cancer and ketogenic diet, but never linking the two things?
Marco
I didn't mean to imply that it was in any way easier to become a vet... I meant that people who may have social issues are more likely to want to be a vet than other medically inclined people (and then these individuals may be at a higher risk for suicide because social issues often go together with other emotional problems).
Sort of like how some mental health workers are rumored to be less mentally stable than other health professionals... it doesn't necessarily mean being a mental health worker is more difficult than any other health care job... just that the factor of working with mentally ill people may attract individuals who are a little mentally ill themselves.
Then again, I don't know much about vets, and if what you said was true it does sound like an extraordinarily stressful profession.
"To reject vegetable food complepetely would be too wasteful of available resources."
Hello Peter,
I'm glad you raised this point. The papers on Fiaf (Fasting induced adipose factor) mention the conversion of starch and fiber to SFA by the gut microbiota.
A few points can be made about this overlooked contribution by the gut flora to overall health:
1. It explains the Kitavan Paradox if there is one.
2. Usable energy (by the host) through the consumption ot starch and fiber may haven been under-estimated without taking into account the positive energy/caloric contribution by the bacteria - our own compost heap. The familiar "a calorie is a calorie" argument and the citing of the laws of thermal dynamics miss this point.
3. One can fuel the body by carb but run it in fat.
Kudos to you for posting on the Fiaf papers. This conclusion from one paper is particularly relevant:
"...these findings support the notion that the gut microbiota can influence both sides of the energy balance equation, and underscore the importance of considering our metabolome in a supraorganismal context."
John
Hi Marco
The similarity between glucose and ascorbate has all sort of ramifications relating to heart disease and cancer, but they seem quite complex. As regards ascorbate for cancer, there seems to be quite good evidence that it is an effective chemotherapeutic agent in vitro at concentrations easily available from intravenous infusion in vivo. Obviously this is relevant to the Pauling Cameron study from the Leven Hospital in Scotland (10g/d IV for 10 days). Looks like free radical generation and apoptosis induction might be the mechanism. Don't have the papers to hand and not sure how well it fits in with ketogenic diets.
Undoubtedly high dose IV ascorbate is chemotherapy, it's not really nutrition. It does seem a great deal safer than a lot of chemotherapies, the question is how effective it is in vivo. Would need a decent trial, unlike the Mayo trial which was supposed to repeat the Leven study but omitted the IV doses of ascorbate. Oops. I don't think you could achieve chemotherapeutic concentrations orally, even with ketogenic hypoglycaemia to help. But really dunno on that one.
PS The Pauling/Cameron paper was only published in Proc Natl Acad Sci USA, Eades has a lot to say about this type of publication (poor peer review).
Peter
Johnn,
I have enormous respect for bacteria, gut and elsewhere. They've been playing evolution for a lot longer than we have, though that may be a wrong way of looking at it... after all we're probably all bacteria/archaebacter derived organisms.
Peter
Peter, Michael Eades said in one of his recent posts that you need more salt on a low-carb diet, esp in the beginning phase. I think this might have something to do with the usual advice to drink lots of water. That causes electrolyte imbalances which lead to problems like cramps on low carb diets. Raw meats might prevent this water loss, based on anecdotal reports from people feeding animals raw meat. Avoiding dried foods like cheese might also be a good idea. I have noticed that Jan K. encourages liberal water intake and people who eat his diet say they need to drink more water. There are many reasons, I think, it would be a good idea to avoid drinking water. For starters, most water is deliberately poisoned with fluoride or chlorine bleach. I believe it would be healthier to do anything we can to avoid drinking a water source contaminated with such hazardous chemicals.
Peter,
No criticism intended on the earlier post. I was just musing about whether human can be part-time ruminant - a vegetarian diet with lower demand on insulin and more suitable for this over-populated Earth.
Johnn,
Yes, this is a niche which has been exploited pretty well by rabbits and guineapigs (who still require coprophagia to fully absorb nutrients) and par excellence by the equidae (who don't). All hind gut fermenters and very successfull, running of volatile fatty acids and using minimal insulin until domesticated. Not sure about the PCRM and their dietary habits. I don't really think real humans could go this route with our canine/feline style gut. If we could, and the Earth then supported 60 billion people, where would we get oil for all those SVUs? There are only so many Iraqs.
Peter
"To reject vegetable food completely would be too wasteful of available resources."
I disagree. Growing rabbit food and transporting it by truck is a waste of resources. If you want to grow a few things in your own garden, that might be a good use of resources. I don't know. It seems wasteful to me for stores to sell foods like green vegetables, tomatoes, berries, etc.
I'm thinking evolution-wise. Digging up a sweet potato which has been storing starch for its own use in the future and stealing it's future existence strikes me as a good use of 60 seconds with a grubbing stick. Humans are clever. And remarkably stupid at the same time, eg growing green leaf vegetables nowadays and regarding them as bulk food.
Peter
http://jn.nutrition.org/cgi/content/full/127/10/2000
This is a paper that estimates calories from short chain fatty acid synthesis in the colon for the Western Lowland Gorilla. Including fermentation, fat comes in at 60 percent of calories. Carbs at 16 percent. But an almost all greens diet really puts the whole slow-carbs stuff to the test, the carbs are probably absorbed at such a rate that gluconeogenesis is just slightly tamped down.
David Jenkins was involved with that study. He did another study where he tried to feed people an all vegetable and fruit diet, but he had to add about a cup of nuts to keep them from losing weight. They spent a solid eight hours a day just eating. The amount of food was ridiculous, I think it was over ten pounds. By the time you take a lot of this stuff (I mean the Dean Ornish Eat more weigh less stuff) to the extremes necessary to achieve desireable therapeutic results, the diet just isn't practical. They test at the extremes, then they advise more moderate approaches that don't actually do anything.
Peter:
With 60B folks fattening on grain, alternative energy research had better get started on plan to recycle oil through liposuction. I'm pretty sure surgery can be employed to stretch the length of the colon to enhance its fermenting efficiency.
There's this growing horde of plant-eaters goaded by this catchy mantra with Haiku-like simplicity: "Eat food, not too much, mostly plant." The middle part of which seems difficult to implement without help if you're constantly in a graze mode.
Johnn,
Don't forget to harvest the methane produced too, with the price of gas in the UK we could do with more high fiber humans contributing to the national gas supply. Practicalities again impinge, but perhaps a flatulence storage organ could be implanted and vegans could then off load twice a day at specialised gas collection points... Dunno as I like the image much!
Peter
Hi Donny,
Was he involved in the Paignton Zoo entertainment-pseudoscience documentary? If I had a little more time I'd have blogged on it ages ago. Another "gathering was good for a week" diet!
"honey, hazelnuts and fresh fruits and vegetables like watercress, broccoli, carrots, cabbage, tomatoes, radishes, strawberries, melons, mangoes, apricots, bananas, plums, figs and Satsuma mandarins"
I'd love to see many HGs eating this way!
Peter
This "study"?
"...other great apes are very effective hindgut fermentors (Milton and Demment 1988, Van Soest 1994). The sacculated colon of humans led Elliot and Barclay-Smith (1904) to conclude that the colonic structure of humans is closer to that of a herbivore than to an omnivore."
Is that true? Is the digestive tract of apes similar to humans´?
Nope, not that study. Very similar protocol and results, though. I always have trouble digging the study up because searches generally result in the zoo study you posted. I'll find it later and post it.
For Chainey:
The French must be in a creative mood in naming fermented cream "fresh cream" - the English translation for creme fraiche. You can easily make it at home just like making yogurt by substituting heavy cream for milk.
Slowing down the fermentation by chilling the cream (overnight) half-way through yields more delicate flavor. Top that on berries with a few drops of balsamic vinegar and maple syrup is my favorite dessert.
I recall Peter commented previously to the effect that fermented cream can undo the damage of Pasteurization. Perhaps, by straightening out the damaged protein with their own HSP, or digesting and then reconstituting it? I'd like to think the bacteria makes the milk alive again with the new enzymes.
"I'm thinking evolution-wise. Digging up a sweet potato which has been storing starch for its own use in the future and stealing it's future existence strikes me as a good use of 60 seconds with a grubbing stick."
True, but how many grow potatoes in their back yards? Most are shipped. We need to change our whole concept of nutrition to rely on dense foods rather than high-fiber rabbit food.
"Humans are clever. And remarkably stupid at the same time, eg growing green leaf vegetables nowadays and regarding them as bulk food."
Vegans use lots of stupid arguments like saying it takes so many pounds of grain to make one pound of meat, but who can eat 20 pounds of grain, or whatever it would be? We evolved to eat a low-fiber diet, IMO. A lot of tribes ate no-fiber diets. Using land to grow rabbit food is a worse waste of resources than feeding the cows grain, IMO.
Here's another example. It would be much smarter to import coconut oil than to import bananas, if you look at the cost-per-calorie side of the equation. Michael Pollan's axiom to "eat food, not too much, and mostly plants" is 2/3rds right.
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