I had a very pleasant chat with Paul Saladino.
It was quite a long chat and there were still lots of places that we did not have time to visit...
Peter
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You need to get calories from somewhere, should it be from carbohydrate or fat?
About Me
- Peter
- I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
Organisation (or lack of it)!
The "labels" function on this blog has been used to function as an index and I've tended to group similar subjects together by using labels starting with identical text. If they're numbered within a similar label, start with (1). The archive is predominantly to show the posts I've put up in the last month, if people want to keep track of recent goings on. I might change it to the previous week if I ever get to time to put up enough posts in a week to justify it. That seems to be the best I can do within the limits of this blogging software!
Blog Archive
Labels
- !Kung Bushmen and mongongo nuts again (1)
- !Kung Bushmen and mongongo nuts yet again (1)
- A aargh BROKEN LINKS (1)
- A bit more on ketones and diabetic nephropathy (1)
- A brief aside in to statins and FH and all cause mortality (1)
- A brief discussion of ketosis (1)
- A defect of fat metabolism and a few thanks (1)
- A glimmer of light (1)
- A heads up (1)
- A little more on PCSK9 inhibitors (1)
- A load of crap in Gartnavel (1)
- A Peek at Paleo (1)
- A post not about Walter Kempner (1)
- A tale of two abstracts (1)
- A wander off in to dietary protein calories (1)
- ACCORD and musings on insulin (1)
- Acetoacetate and arterial oxygen tension (1)
- Acetone to oxaloacetate (1)
- Acipimox (2) and weight gain (1)
- Acipimox and insulin (1)
- Acipimox and insulin action (1)
- Adipose triglyceride lipase knockout mice (1)
- Adipotide and the Bad Fat (1)
- Adrian Ballinger on Everest (1)
- AGE RAGE and ALE (1): The AGE of LDL (1)
- AGE RAGE and ALE (2): The ALE of LDL (1)
- AGE RAGE and ALE (3): oxLDL (1)
- AGE RAGE and ALE (4): segregation (1)
- AGE RAGE and ALE (5): fasting (1)
- AGE RAGE and ALE (6): low fat (1)
- AGE RAGE and ALE (7): VLDL degradation (1)
- AGE RAGE and ALE (8): VLDL degradation and Krauss (1)
- AGE RAGE and ALE (9): VLDL degradation and Fish Oil (1)
- AGE RAGE and ALE posts (10): small dense Krauss (1)
- AGE RAGE and ALE posts (11): linoleic acid (1)
- AHA approved egg! (1)
- Alcohol and fructose are the same to your liver (1)
- Alcohol and weight loss (1)
- Alzheimer's (1)
- Alzheimers and ketones (1)
- Alzheimers and omega 6s (1)
- Alzheimers and Tau proteins (1) (1)
- Alzheimers and Tau proteins (2) (1)
- Amgen share price and PCSK9 inhibition with Repatha (1)
- Amgen share price and PCSK9 inhibition with Repatha (2) (1)
- an aside (1)
- An aside on psychiatric links from Sid Dishes (1)
- An embarrassment of cress (1)
- An Error (1)
- An exchange of half bricks (1)
- Anacetrapib and phytotoxins (1)
- Anger vs diet in Japan (1)
- Animal fat and cholesterol (1)
- ARDS and linoleic acid (1)
- ARDS and Tucker Goodrich (1)
- ARDS isoprostanes and isofurans (1)
- Are COVID-19 vaccines useful? (1)
- Are COVID-19 vaccines useful? (2) (1)
- Are COVID-19 vaccines useful? (3) (1)
- Are humans just multicellular yeasts? (1)
- Are ketone esters dangerous? (1)
- Are you lino-philic? (2) (1)
- Are you on clenbuterol? (3) (1)
- Are you trans-phobic? (1) (1)
- Arteriosclerosis (1) in 1957 (1)
- Arteriosclerosis (2) and sulphation factor (1)
- Arteriosclerosis (3) and von Willebrand Disease (1)
- Arteriosclerosis (4) GAG and sudden death (1)
- Arteriosclerosis (5) GAG and sudden death part two; the pictures (1)
- Arteriosclerosis (6) and Subbotin (1)
- Arteriosclerosis and saturated fat (1)
- Arteriosclerosis and the breeder rat (1)
- Arteriosclerosis images (2): Models (1)
- Athletic acid reflux (1)
- Atrial tachycardia and fibrillation (1)
- Axen and Axen (1) (1)
- Axen and Axen (2) (1)
- Axen and Axen (3) Hawks (1)
- Axen and Axen (4) Ketogenic insulin resistance. It's all over now... (1)
- Axen and Axen (5) The tradition continues (1)
- Back on line (2)
- Back to a semblance of normality: A couple of conversations (1)
- BAM15 and semaglutide are not insulin sensitising (1)
- Barja (1)
- Best ever statin study comment? (1)
- Best ever statin study? (1)
- Beta oxidation intermediates control ETC function (1)
- Blood "energy" content (1)
- Bob Michell on meta-analysis (1)
- Boiled mashed potatoes for miracle weight loss? (1)
- Boxes (1)
- Brain on a statin (1)
- Brain on chocolate (1)
- Brand insights (1)
- Brand on 4-HNE facilitated uncoupling (1)
- Breast cancer and starch (1)
- Breast cancer BRCA1 and metabolic syndrome (1)
- butter and leptin receptors: Speculation! (1)
- Butter gives you fatty liver! Again. (1)
- Butter insulin and Dr Davis (1)
- Butter vs peanut butter (1)
- Can linoleic acid keep you slim? (1)
- Cancer and ketones (1)
- Cardiac ischaemia and low carbohydrate diets (1)
- Casein and gluten and gastric pH (1)
- Casein vs gluten (1)
- Cat rawfeeding; scroll down the comments (1)
- Cell surface oxygen consumption (1) (1)
- Cell surface oxygen consumption (2) (1)
- Cell surface oxygen consumption (3) (1)
- Cell surface oxygen consumption (4) Influenza (1)
- Chicken fillets are not meat. If you're a cat. (1)
- Cholesterol (the HDL sort) kills? (1)
- Cholesterol and Carruthers (1)
- Cholesterol and cholestyramine (1)
- Cholesterol and heart attack survival (1)
- Cholesterol and innate immunity (1)
- Cholesterol and memory (1)
- Cholesterol and Son of J-LIT (1)
- Cholesterol and the J-LIT study (1)
- Cholesterol and the J-LIT update (1)
- Cholesterol fed rabbit (1)
- Cholesterol heart attacks and JUPITER (1)
- Cholesterol hypothesis in 2010 (1)
- Cholesterol hypothesis in 2010 part 2 (1)
- Cholesterol JUPITER link (1)
- Cholesterol Milano style (1)
- Cholesterol pacitimbe and ACAT (1)
- Cholesterol presentation: Between countries (1)
- Cholesterol ratios through the looking glass (1)
- Cholesterol ratios: Torcetrapib again (1)
- Cholesterol reflectivity at 400nm (1)
- Cholesterol within nations studies (1)
- Cholesterol; it's not a competition (1)
- Cholesterol; MESA and EBCT (1)
- Cholesterol; statins kill? (1)
- Cholesterol: ASTEROID destroys lipid hypothesis (1)
- Cholesterol: Do chylomicrons clog your arteries? (1)
- Cholesterol: Do chylomicrons clog your arteries? (2) (1)
- Cholesterol: LCAT and rabbits (1)
- Cholesterol: LDL in Oslo (1)
- Cholesterol: More epidemiology (1)
- Cholesterol: Near miss in Edinburgh (1)
- Cholesterol: Peto seeing some light? (1)
- Cholesterol: statins and oxLDL (1)
- Choose your insulin sensitivity well (1)
- Cirrhosis and corn oil (1)
- Cirrhosis and fish oil (1)
- Cirrhosis and fructose (1)
- Clofibrate and PUFA (1)
- Coconut oil and obesity (1)
- Coconuts and Cornstarch in the Arctic? (1)
- Coffee (1)
- Colorectal cancer and cholesterol (1)
- Colorectal cancer; fiber and the PPT (1)
- Complex I: Hoffer and B3 (1)
- Complex IV and control of delta psi (1)
- Conditioning Research on bad carbs (1)
- Confirmation Bias in my head (1)
- Confirmation bias is not just in my head (1)
- Confirmation bias is so nice (1)
- Coronary Artery Calcium Score and Scleroderma (1)
- Coronavirus is possibly everywhere (1)
- Costa del Glasgow (1)
- Covid playground (1)
- COVID-19 (1)
- CPT1aL479 resurfaces nicely (1)
- Crabtree and cardiovascular surgery (1)
- Credo (1)
- Cynthia Kenyon link (1)
- Dave Asprey and Dr Veech (1)
- David Blaine and refeeding syndrome (1)
- Dead people DO bleed... (1)
- Death by dogma (1)
- Delta psi and insulin and ROS (1)
- Delta psi and ROS (1)
- Denmark purchased using Flora profits? (1)
- Deuterium protected linoleic acid (1)
- DHA in rats (1)
- Diabetes and cardiac apotosis (1)
- Diabetes and hunger (1)
- Diabetes in Sweden (1)
- Diabetes in Sweden update (1)
- Diabetes; endothelial damage (1)
- Diabetic and hungry? (1)
- Diabetic nephropathy and the lost Swede (1)
- Diagnosing and Treating Vitamin B12 Deficiency Video (1)
- Do you believe in MRI scanners? (1)
- Dodgy D'Anci (1)
- Double Bond Index and longevity in humans (1)
- Dr Davis links (1)
- Dr Doug Wallace on mitochondria (1)
- Dr Ravnskov on statins for primary prevention of CVD (1)
- Dr Uffe Ravnskov MD PhD interview (1)
- Dr Wolfgang Lutz Obituary (1)
- Dunnigan Familial Partial Lipodystrophy (1)
- Earning a crust (1)
- Easiyo (1)
- Eat as much starch as you wish (1)
- Eating lots of meat and nothing much else (1)
- EBCT scan (1)
- EFA deficiencies? (1)
- Eggs are here (1)
- Eggs in Ontario (1)
- Electrochemistry (1)
- Electrochemistry (2) Superoxide (1)
- Electron Transport Chain image (1)
- Endocannabinoids in brain and adipocytes (1)
- Endotoxin Absorption on a High Fat Diet (1)
- Endurance and oxygen flux during fatty acid oxidation (1)
- Energy expenditure in obese vs slim non dieters (1)
- EPIC HbA1c and heart attacks (1)
- Essential fatty acids are essential (1)
- Excession (1)
- Faking it with selenium (1)
- Familial Hypercholesterolaemia (1)
- Familial Hypercholesterolaemia and glucose (1)
- Familial Hypercholesterolaemia and porcelain (1)
- Familial Hypercholesterolaemia Brown and Goldstein (1)
- Familial Hypercholesterolaemia heterozygous survival (1)
- Fancy some serology? (1)
- Fancy some serology? (2) (1)
- Fancy some serology? (3) In Japan (1)
- Fasting insulin and weight loss (1)
- Fasting insulin and weight loss and calories-in vs calories-out (1)
- Fasting insulin and weight loss on a water fast (1)
- Fat storage and retrieval (1)
- Fathead Supersize Me and Sweden (1)
- Fathead Supersize Me and Sweden (2) (1)
- Fats and absorbing endotoxin (1)
- Feeling experimental? (1)
- FFA vs 4-HNE for activating uncoupling (1)
- Fiaf (1) Who's fat is it anyway? (1)
- Fiaf (2) starving amidst plenty (1)
- Fiaf (3) where next? (1)
- Fiaf (4) memes and fat (1)
- Fiaf (5) Meme Watching (1)
- Fiber inulin and cancer (1)
- Fiber sucrose and ulcers (1)
- FIP vaccines etc (1)
- FIRKO mice (1)
- FIRKO-isation without all the hassle? (1)
- FIRKO-ise (1)
- First meat (1)
- Flow Mediated Dilation: What does it mean? (1)
- Foie Gras (1) Peroxisomes (1)
- Foie Gras (10) Liver (1)
- Foie Gras (11) Hepatocyte mitochondria (1)
- Foie Gras (2) Lard fed rats (1)
- Foie Gras (3) carbohydrate (1)
- Foie Gras (4) RER (1)
- Foie Gras (5) An aside on how to stay slim (1)
- Foie Gras (6) inflammatory mRNAs (1)
- Foie Gras (7) What do you mean by inflammation? (1)
- Foie Gras (8) Vaughan's macrophages (1)
- Foie gras (9) Adipocyte ROS (1)
- Foie gras from safflower oil hiatus (1)
- Folate and homocysteine (1)
- Follow on to Tucker's post on PUFA in rats (1)
- Food fermented cream (1)
- Food; carnitas (1)
- Food; chicken salsa (1)
- Food; Mutton followed by cheesecake (1)
- Food; sausages (1)
- Food; steak and kidney casserole (1)
- Food: African Beef Stew (1)
- Food: Burgers (1)
- Food: Lardo; the real thing (1)
- Food: Liver and bacon (1)
- Food: Liver; can you over do it? (1)
- Food: Mutton or lamb in orange sauce (1)
- Food: Offal (1)
- Food: Optimal ice cream (1)
- Food: Pork in green salsa and random dessert (1)
- Food: Recipe group (1)
- Food: steak and kidney casserole (1)
- French paradox in Sweden (1)
- From Yeasts to Chloroquine (1)
- Fructose (01) There's a signal (1)
- Fructose (02) Obesogen (1)
- Fructose (03) NOX vs RET (1)
- Fructose (04) Normal Adults (1)
- Fructose (05) Four out of five diabetics (1)
- Fructose (06) Acipimox tangent (1)
- Fructose (07) Acipimox tangent II (1)
- Fructose (08) Acipimox and FFAs (1)
- Fructose (09) The Surwit hepatocyte (1)
- Fructose (10) A can of cola (1)
- Fructose and gout (1) (1)
- Fructose and gout (2) (1)
- Fructose and heart attacks (1)
- Fructose and lactic acid in Naked Mole Rats (1)
- Fructose and leptin (1)
- Fructose and lipolysis (1)
- Fructose and metabolic syndrome: Uric acid (1)
- Fructose and triglycerides (1)
- Fructose Glucose and Cholesterol (1)
- Fruit and vegetables (1) cause DNA damage (1)
- Fruit and vegetables (1) re post (1)
- Fruit and vegetables (10) WHI and cancer (1)
- Fruit and vegetables (11) link (1)
- Fruit and vegetables (12) WHEL and CVD (1)
- Fruit and vegetables (13) become eggs (1)
- Fruit and vegetables (14) Listeriosis is no fun (1)
- Fruit and vegetables (2) damage your DNA... latest study headline (1)
- Fruit and vegetables (3) last post (almost) (1)
- Fruit and vegetables (4) The asterisk (1)
- Fruit and vegetables (5) in Holland (1)
- Fruit and vegetables (6) WHEL study (1)
- Fruit and Vegetables (7) Mediterranean France (1)
- Fruit and vegetables (8) WHEL study and McDougall (1)
- Fruit and vegetables (9) potato fruits (1)
- Fruit Flies and NDI1 (1)
- FSA apple (1)
- FSA in Glasgow (1)
- Full blown linoleic acid deficiency: speculation (1)
- Getting fat (1) staying fat (1)
- Getting fat (2) staying fat; follow on (1)
- Getting fat (3) is good (1)
- Getting fat (4) is bad when you stop (1)
- Getting fat (5) Hunger (1)
- Getting fat is good (6) Official (1)
- GLP-1 agonists (1)
- Glucosamine and aged mice (1)
- Glucose as a cure for hypertriglyceridaemia? (1)
- Glucose from fatty acids: RQ of 0.454 (1)
- Glucose lactate and cancer (1)
- Gluten and cardiomyopathy (1)
- Gluten and gall bladders (1)
- Gluten and NK cells (forget the antibodies) (1)
- Gluten and rheumatoid arthritis (1)
- Gluten and schizophrenia SPECT scan (1)
- Gluten ataxia (1)
- Gluten coeliac and multiple sclerosis (1)
- Gluten Dr Briffa link (1)
- Gluten links from Bloggeier (1)
- Gluten poppy pictures (1)
- Gluten-Congratulations: You have coeliac disease (1)
- Gluten; thyroid and auto immunity (1)
- Gluten: Does coeliac disease require an infection? (1)
- Gluten: Not your average plant toxin? (1)
- Gluten: The NICE guidelines for UK diagnosis (1)
- Glycaemic load and breast cancer (1)
- Gourmand Rats? (1)
- Great Barrington Declaration (1)
- Great Barrington Declaration (2) (1)
- Green Tea Extract; superb antioxidant? (1)
- GSD IIIa ketones MAD and Veech again (1)
- GSD type I vs GSD type III: Cornstarch vs ketones (1)
- Guddling in the dark (1)
- Guddling in the dark for a respiratory quotient (2) (1)
- Guess the weight of the mouse competition (1)
- Gwyneth Paltrow has osteopaenia (1)
- Hall and CICO again (1)
- Hall and CICO part 2 (1)
- Hall and CICO part 3 (1)
- Have you thought about electron transporting flavoprotein dehydrogenase and its substrate electron transporting flavoprotein? (1)
- Hazel eats butter (1)
- HbA1c and Familial Hypercholesterolaemia (1)
- HbA1c: Crack vs smack for a lower reading? (1)
- HbA1c: Low glucose and acid (palmitic) (1)
- Heart failure and insulin resistance (1)
- Helicobacter and glucose (1)
- Helicobacter and hydrogen (1)
- Hepatic extraction of fructose (1)
- Hepatic insulin resistance (1)
- Hepatic insulin resistance in KD fed mice (1)
- Hepatic insulin resistance through caloric overload (1)
- Here we go in to Lockdown 2 (1)
- Heroin and IBS (1)
- High fat diet and fertility (1)
- High fat diets make you fat and stupid (1) (1)
- High fat diets make you fat and stupid (2) (1)
- High fat Dutch style (1)
- High fat fed mice on stearic acid (1)
- High fat meal is analgesic (1)
- HLA-B27 and Ebringer (1)
- HLA-B27 and Ebringer BSE text (1)
- HLA-B27 and Ebringer speech text (1)
- HLA-B27 some more (1)
- Holiday reading (1)
- How can insulin resistance cause weight gain? (1) ALDH2 (1)
- How can insulin resistance cause weight gain? (2) 0.1 μM (1)
- How can insulin resistance cause weight gain? (3) AD-9308 (1)
- How can insulin resistance cause weight gain? (4) amplification (1)
- How can insulin resistance cause weight gain? (5) MCTs (1)
- How incomplete was LUCA? (1)
- HOW MANY bananas a day? (1)
- How many eggs per day? (1)
- How much linoleic acid to get fat and insulin resistant? (1)
- How toxic is wheat? (1)
- How's it going (1)
- Hunting gathering and starving (1)
- Hyperglycaemia and free radicals (1)
- Hyperglycaemia is bad (1)
- Hyperlipid Protons ambassadors (1)
- I'm back (1)
- If there were time... (1)
- IgG IgA and sniffing a virus (1)
- IgG IgA and sniffing a virus which stinks (1)
- IHD and ghee (1)
- IHD single vessel disease (1)
- IHD Tracking plaque 1950s style (1)
- Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state (1)
- In the gym (1)
- Inhibiting lipolysis using acipimox (1)
- Insulin and confusion (1)
- Insulin and the Rewards of overfeeding (1)
- Insulin detemir (1) (1)
- Insulin detemir (2) (1)
- Insulin detemir (3) (1)
- Insulin glucagon and protein (1)
- Insulin in the brain: Hyperphagia? (1)
- Insulin in the brain: off topic giggle (1)
- Insulin increases coupling in mitochondria (1)
- Insulin makes you hungry (1) (1)
- Insulin makes you hungry (10) Processing (1)
- Insulin makes you hungry (2) even in the presence of hyperglycaemia (1)
- Insulin makes you hungry (3) a matter of semantics and free fatty acids (1)
- Insulin makes you hungry (4) unless you keep it out of your brain (1)
- Insulin makes you hungry (5) except when you resist (1)
- Insulin makes you hungry (6) except when you snort it (1)
- Insulin makes you hungry (7) superoxide is satiety (1)
- Insulin makes you hungry (8) Blokes (1)
- Insulin makes you hungry (9) Women (1)
- Insulin mimesis and NOX enzymes (1) A principle (1)
- Insulin mimesis and NOX enzymes (2) Lactate (1)
- Insulin mimesis and NOX enzymes (3) MCT (1)
- Insulin mimesis without NOX enzymes (4) MCT (1)
- Insulin mimesis without NOX enzymes (5) MCT plus linoleic acid (1)
- Insulin mimesis without NOX enzymes (6) MCT versus linoleic acid (1)
- Insulin sensitivity makes you fat (1)
- Insulin sensitivity makes you fat: growth hormone receptor deletion (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (02) (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (03) Visceral vs subcutaneous (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (04) M scores (1)
- Insulin; the Un-dead and coffin nails (1)
- Insulin: Are you hungry? (1)
- Insulin: Are you hungry? Part 2 (1)
- Insulin: The Flatline Days (1)
- Intellectual honesty vs obfuscation (1)
- Interesting times on Mars (1)
- Intimal wall volume reductions with weight loss (1)
- Is the astrocyte-neuron lactate shuttle finished? (1)
- Is vaccine efficacy a statistical illusion? (1)
- It's never too late to normalise your glucose (so long as you are still alive) (1)
- Jan Kwasniewski comment (1)
- Japan and a Seven Countries Study follow on (1)
- Jay Bhattacharya in conversation with Lord Sumption (1)
- Jebb VS Nutt (1)
- Jimmy Moore on Dr Weil (1)
- John Hawks on Paleo in NY (1)
- Junk Food binge (1)
- Just a heads-up (1)
- Just a little on complex I and models (1)
- Just an announcement (1)
- Just an update (1)
- Kebabs (1)
- Ketoacidotic death in lactation! (1)
- Ketogenic Diet: Eat Food (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe (2) (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe. (1)
- Ketogenic vs moderate carbohydrate diets (1)
- Ketones for ALS? (1)
- Ketones in Tehran (1)
- Ketones without the side order of Danish Pastry please (1)
- Ketones: Should idiots be allowed to write the methods section of any "scientific" paper? (1)
- Ketosis and Protein (1)
- Ketosis links (1)
- Kitava: uric acid (1)
- Kwasniewski and cancer (1)
- Kwasniewski paper (1)
- Kwasniewski; praise the lard (1)
- Lactate as bulk energy transport (1)
- Lard makes hungry mice live longest (1)
- Latest obesity paradox (1)
- Let them eat fat: Ron Rosenbaum (1)
- Life (01) Random musings on carbon monoxide (1)
- Life (02) Polyprenyl derivatives at the origin of life (1)
- Life (03) ATP synthase (1)
- Life (04) On the bench top (1)
- Life (05) Why sodium ions? (1)
- Life (06) What's wrong with sodium ions? (1)
- Life (07) Two timelines (1)
- Life (08) Proto-Ech (1)
- Life (09) Ech (1)
- Life (10) Methyltransferase in methanogens (1)
- Life (11) Ferredoxin (1)
- Life (12) Loki and its membrane potential (1)
- Life (13) Skulachev in 1978 (1)
- Life (14) From Skulachev to LUCA (1)
- Life (15) Skulachev addendum (1)
- Life (16) Mulkidjanian: Na+ pump or Na+/H+ antiporter? (1)
- Life (17) Nick Lane on Proto-Ech (1)
- Life (18) Why stop at formaldehyde? (1)
- Life (19) Metallic iron and the origin of metabolism (1)
- Life (20) How primordial is oxidative phosphorylation? (1)
- Life (21) Pyrococcus furiosus (1)
- Life (22) FeNi hydrogenase (1)
- Life (23) Antiporting: Choose your ion well (1)
- Life (24) Porting over CCCP (1)
- Life (25) Left or right hand? (1)
- Life (26) MrpA MrpD NuoL NuoM and NuoN. Plus nt-Nha. (1)
- Life (27) Alphabet soup (1)
- Life (28) Proton Billiards (1)
- Life (29) Applied billiards to MRP and MBH (1)
- Life (30) Guesses about Na+ channels (1)
- Life (31) Chinese whispers (1)
- Life (32) On the correct side of the fence (1)
- Life (33) Transient hunger (1)
- Life (34) Complex I pumping (1)
- Life (35) NiFe pumping (1)
- Life (36) Complex I. Protons are large (1)
- Life (37) Just a gif of complex I (1)
- Life (38) Water Wires (1)
- Life (39) NuoH (1)
- Life (40) Proton pumping (1)
- Linoleic acid and Tuberous Sclerosis (1)
- Linoleic acid makes you hungry (1)
- Linoleic acid panel discussion (1)
- Lipid blockage (1)
- Lipoprotein(a) a prickly subject (1)
- Lipoprotein(a) and ascorbate (1)
- Lipoprotein(a) and DELTA (1)
- Lipoprotein(a) and genetics (1)
- Lipoprotein(a) and oxidised cholesterol (1)
- Lipoprotein(a) and oxidised lipids: What's your mimium requirement? (1)
- Lipoprotein(a) and the Fairies at the bottom of my garden (1)
- Lipoprotein(a) and tissue transglutaminase (1)
- Lipoprotein(a) Bantu recap (1)
- Lipoprotein(a) Bantu recap 2 (1)
- Lipoprotein(a) genetics press release (1)
- Lipoprotein(a) is oxidised (1)
- Lipoprotein(a) Oxford abstract (1)
- Lipoprotein(a); Bantu Lp(a) and Swedish Lp(a) (1)
- Lipoprotein(a): 7-ketocholesterol and cancer (1)
- LIRKO mice (1) (1)
- LIRKO mice (2) (1)
- LIRKO mice (3) The MCQ (1)
- live humans. They're just like mice! (1)
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15 comments:
Of course, some folks have already referred to this interview on the Great Barrington Declaration post.
I just want to say, in addition to the content, I greatly appreciate that the audio volume level was good. I've only heard one other interview with Peter (no video), and even with my laptop speakers turned all the way up, I could barely make out what Peter said. Partly it's the accent which is very strong to my American ears. Recorded more loudly would have helped.
I have the same problem with audio of Malcolm Kendrick. He has a soft voice to go with the Scottish accent, and without amplification it's very hard to try and listen.
Good job!
Hi, interesting discussion, thank you.
The transient insulin resistance due to ROS from negative electron flow, how transient is this? Assume that this is repeated as long as the cell has extra calories to burn.
So, 4-HNE does similar thing i.e. transient insulin resistance. How does these two fit together, burning polyunstable fats does not make ROS, which does not then induce insulin resistance, however burning results in 4-HNE, which induces insulin resistance? Am I missing something in here?
rgds JR
Regarding the fat cell size, they found an interesting difference in Dietfits; lower carbers had smaller fat cells than higher carbers. The main finding in Dietfits was next to nill, no weight difference, but this fat cell size difference should be interesting. https://www.healio.com/news/endocrinology/20191205/despite-similar-weight-loss-lowcarbohydrate-diet-delivers-insulin-reductions-smaller-fat-cells-than
Looking forward further report on this...
JR
Great podcast Peter. Careful, now that people like Saladino and Marshall are taking your ideas more mainstream, you'll end up nailed to your cross. Still, on the plus side, people are hearing about your ideas and that's generally a Good Thing.
JR - I read your link and had to wonder - if the low fat dieters' fat cells are NOT shrinking significantly when they lose weight, it can only mean one of two things. Either the at cells are dying off, which sounds unlikely, or the lost body mass is coming from somewhere else. Muscle tissue perhaps? Strange that the question was never asked, at least in the article.
Lots to think about, as usual! On the reverse electron flow to indicate enough energy, it reminded me of this paper called "The Randle cycle revisited: a new head for an old hat". What they are saying is that the Randle cycle is broken under only 2 conditions: stress, which I understand is fight/flight stress, or eating high carb and high fat simultaneously. Here's a quote from the section subtitled Glucose toxicity:
"An overabundant diet rich in carbohydrates and fat (184) should force-feed electrons from glucose into the respiratory chain, in which the already prevailing high ΔΨ prevents electron flow. This excessive energy supply, not matched by energy demand, will further worsen the jamming of electrons in the respiratory chain and eventually result in massive ROS production and mitochondrial damage (Fig. 7)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/
The condition of high carb plus high fat might be something to add to your analysis.
Outstanding podcast. A couple thoughts:
When you say RET causes electrons to squirt back through Complex I, does that mean they do not also go back through Complex II (or any of the other inputs into the co-Q couple)?
Also, I was intrigued by the contrast you talked about between overstretched adipocytes releasing saturated FFAs ( and not PUFAs) in obese people, but in people on a keto diet, they release more PUFAs. Is this the same physiological process causing a different result in the two cohorts, or are the different observations because the fat cells are doing two different things in each group? Thank you.
Hi Uknown, Yes, it’s a nice paper. The concept which is lacking is the physiological role for ROS signalling. If you accept that every single meal is hypercaloric in the absorptive phase you need to look at the physiological role for ROS to stop ingress of calories. This is not damaging… I think the paper is around 2006, people weren’t really thinking along those lines. But the mechanisms at the substrate label are nicely described.
Hi Scrivener, many thanks. There’s a follow on planned. Getting a good handle on the FFA types released under physiological vs pathological conditions is quite difficult because measuring total fatty acids is quite easy, separating them out by subtype tends to need HPLC, rather more involved than sticking plasma in a biochemistry analyser. My main push in this direction was from the Volek group’s paper https://pubmed.ncbi.nlm.nih.gov/18046594/. Mechanism is a “go read some more” subject which is still waiting.
The source of ROS is pretty well everywhere if you set up the mitochondrial model to show this. The interesting papers are those which consider what the physiological sources might be. If you use an inhibitor of complexes at or close to complex V electrons will, undoubtedly, spew out everywhere.
Peter
This was mind-blowingly brilliant. Thank you,Peter
I so enjoyed the interview, Peter!! Thank you for sharing your time so that more people get to hear a bit of your ideas.
Excellent interview, explaining the concepts really well. With Saldaino and Brad Marshall giving you so much coverage you are going to be famous soon..... I never thought of you as a guru!
Hi Susanna, thank you, you are very welcome.
Absolutely Chris. Neither did I. Nor do I now!!!!!
Peter
Would someone going to a high-SFA diet à la the Protons Theory (even from a “dirty keto” diet) expect an increase in dietary intake needs for electrolytes? Is there a mechanism or reason to think that switching to a high-SFA/low-PUFA substrate in mitochondria increases the demand for intracellular electrolytes Mg++ and/or K+? Does increasing the number of mitochondria generally increase intracellular electrolyte requirements?
Can't help there Scrivener, not something I've looked in to.
Peter
Part 2 just got posted. https://www.youtube.com/watch?v=PQMjDtCeXlQ
'Tis true
Peter
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