What REALLY happens when you infuse insulin in to the cerebro spinal fluid of a mouse? You know, the satiety hormone... Just in to the brain, nothing systemic, no hypoglycaemia.
Insulin = big fat adipocytes. Big fat mice. Lovely micrographs.
http://www.jci.org/articles/view/31073/figure/5 will give you the legend.
http://www.jci.org/articles/view/31073 will give you the full text. Might discuss the paper better in a few months time!
But main conclusion:
The brain fine tunes the storage of lipid under the influence of insulin (by increasing fat storage via lipoprotein lipase and also by DNL from glucose). It uses the sympathetic nervous system outflow from the ventromedial hypothalamus to do this. Interpret with caution as these are C57BL/6, mice who may well have some very specific weakness in their ventromedial hypothalamus.
OMG did I laugh when I found this one.
Wanna loose some weight, go eat some potatoes. LMFAO!
Sorry for the crudity. Been on call too long this weekend!
Peter
