Oxidized Low-Density Lipoproteins and Atherosclerosis
S. Ylä-Herttuala1,2, T. Pakkanen1, P. Leppänen1, T. Häkkinen1
Basic research has provided strong evidence that LDL oxidation plays an important role in atherogenesis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstancial evidence that oxidized LDL may be involved in the progression of atherosclerotic vascular disease. Better understanding of mechanisms that lead to LDL oxidation or protect LDL against oxidative damages shouldhelp the development of new strategies for the prevention of cardiovascular diseases. J Clin Basic Cardiol 2000; 3: 87–8.
Just look at this table of comparison between LDL lipoproteins and oxLDL lipoproteins.
If you are measuring the size and numbers of your LDL particles, you might also want to look at their oxidation state too. Perhaps it matters more? Are the small dense LDL particles so associated with atherosclerosis also the most AGEd and ALEd?
Here's the table, click to enlarge
If you had the choice between lots of minimally oxidised LDL and a small amount of highly oxidised LDL which would you choose? Low fat diet anyone, or maybe just more sugar on your soya oil fried donut? Mmmmmmm, yumeeee.
Peter
