Fat Quality Influences the Obesogenic Effect of High Fat Diets
These are the RERs of the rats on the last day of the study. The horizontal lines are the food quotients calculated from the macros of the diets. Under stable conditions 24h RER should equal FQ. These are not stable conditions
It's clear that both groups of rats are catabolising protein for energy in excess of what is present in the diet. More so for the lard diet than the safflower/linseed. They are, undoubtedly, hypocaloric.
The lard based diet rats fail to oxidise lipid despite it being in the diet because they are still sequestering lipid in to adipocytes. Basal lipolysis may be high but hyperinsulinaemia (not measured) from incipient metabolic syndrome is recycling some of that lipid back in to adipocytes. Where it's not being oxidised. The rats are cold and hungry.
The safflower/linseed group have normal fat oxidation, ie equal to FQ, because fat is not being lost in to adipocytes, it's being lost by uncoupling so lipid oxidation on RER is normal. It may provide nothing but heat but the RER looks good. Of course these rats are warm and hungry.
I like it.
Peter
Edit, I don't like the rats being hungry! Just the RER data. End edit.
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