Notice the oxaloacetate (and the citrate off to the bottom right). Now, back in 2012 Chris Masterjohn posted on gluconeogenesis from acetoacetate via acetone and oxaloacetate (Follow the link and this time READ the post). This is his illustration:
Perhaps not as pretty or as comprehensive as my pic but pretty well saying the same thing.
I think it is reasonable to say that both Dr Masterjohn and myself are both fully aware, on record, that acetone from acetoacetate is a substrate for the generation of oxaloacetate.
As Dr M says, fat burns in the flame of oxaloacetate. This does not have to come from glucose. It does not have to come from amino acids. He seems to have forgotten his own post from 2012. Fat provides oxaloacetate. Can anyone imagine that a period of food deprivation would not supply the necessary metabolites to utilise ketone bodies? Well duh.
I know this. He knows this. Now, try this video from this post, starting at about 3 minutes in. I gave up at around 8 minutes, so apologies if he returns to acetone as a source of oxaloacetate later on. It doesn't seem likely from the bits I listened to.
So, the big question is: What happened to Dr Masterjohn's knowledge about ketones and oxaloacetate between July 2012 and August 2016?
This is beyond me. I find it incomprehensible. In 2012 he knew... In 2016??????????
Peter
Thanks to Karl for the heads-up.
