Mea culpa. Sorry all for neglected comments else where on the blog and IRL. Blame Tucker for this link in here... Here's the next post.
Insulin resistance is protective against future weight gain (but not metabolic syndrome!)
Second is this one
in which formerly obese women (ie at high risk of weight regain) are much more insulin sensitive than closely matched control women:
And finally this one:
Insulin sensitivity is increased and fat oxidation after a high-fat meal is reduced in normal-weight healthy men with strong familial predisposition to overweight
in which normal weight, young people with a marked predisposition to obesity are more insulin sensitive than a matched control group:
So, when Tucker presents us with this paper looking at mice engineered to mimic people with reduced ability to detoxify the known generator of insulin resistance, 4-HNE (amongst other molecules)
then I have to think about this graph:
which is very exciting from the Protons perspective. 4-HNE augmentation causes insulin resistance *and* causes obesity. Yet obesity is the result of excessive insulin *sensitivity*, and is clearly visible (in this study) between weeks four and 16, as weights diverge:
Obviously by week 28 both groups of mice are going to be solidly insulin resistant so will gain minimal extra weight. It's weeks 4-16 we're interested in. You don't get fat without storing fat. We use insulin signalling to store fat. Resisting insulin signalling resists fat storage. A paradox, sent to provide insight. That's worth a post in its own right.
Fascinating stuff. Lots to dig in to.
Peter
