Brief aside for a one-liner-ish post.
This study gives an idea of what happens when you drink 4-HNE:
Here are the diets. The rats on heated soybean oil (HO) ate relatively little so all of the other groups were partially starved to the caloric intake of the HO group.
and here are the weight gains (green circles).
Note especially how thin the 4-HNE fed rats (blue rectangle) were and how the fish oil fed rats (red rectangle), even under caloric restriction were still the fattest, fatter even than the fresh soybean oil fed rats. On the same calories.
This diet had no sucrose, it was starch based. Like the rodent chow in the last 4-HNE post which gave the greatest weight gain on DHA or EPA. Starch diets seem worse than sucrose diets when mixed with fish oil...
Back to 4-HNE. These rats were mildly glucose intolerant too. Glucose was ns different from controls throughout an OGTT but the area under the curve was greater under 4-HNE.
In this case we have, I would speculate, 4-HNE causing insulin resistance within adipocytes, limiting fat storage (ie reducing loss into adipocytes), so limiting hunger by actually reducing fat gain.
And doing god only knows what other damage along the way to these un-arguably thin rats. As the authors suggest, the HO diet could even be destroying the beta cells of the pancreas...
Addendum HT to raphi for this link in the comments. Well, that's cool